Anti-thrombotic N-alkylthioakylamino benzenesulfonamides

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...

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260556A, 260556B, 260556AR, 2603977R, 424228, C07C14376, C07C14378, A61K 3118, A61K 3163

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active

042184762

ABSTRACT:
New compounds of the general formula I ##STR1## wherein R.sup.1 and R.sup.2 each independently represent an alkyl group containing 1 to 4 carbon atoms, or an alkoxy group containing 1 to 3 carbon atoms, or halogen, R.sup.3 represents hydrogen, halogen, an alkyl group containing 1 to 4 carbon atoms, an alkoxy group containing 1 to 3 carbon atoms, an amino group or a nitro group, A represents ##STR2## which is bonded to the benzene ring by its sulphur or nitrogen atom and in which R.sup.4 is hydrogen or an alkyl group containing 1 to 4 carbon atoms; together with salts thereof with physiologically acceptable acids and, when R.sup.4 is hydrogen, with physiologically acceptable bases are described. The compounds are of use in inhibiting thrombosis formation, in treating thrombosis and in fibronolytic therapy. Various methods of producing the new compounds are described involving the building up of the --A--CH.sub.2 --CH.sub.2 --S--CH.sub.2 CH.sub.2 NH.sub.2 side chain from aromatic precursors having an incomplete side chain or by introducing at least one of the R.sup.1, R.sup.2 or R.sup.3 substituents into a precursor lacking that substituent or from an amino-protected precursor.

REFERENCES:
patent: 3895010 (1975-07-01), Goralski et al.
patent: 4069254 (1978-01-01), Hidaka et al.
patent: 4098889 (1978-07-01), Dunbar

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