Anti-thrombotic 1,2-benzisothiazolin-3-ones

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...

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260558S, 546198, 546234, A61K 31445, C07D41706, C07D41704

Patent

active

041906632

ABSTRACT:
6-Substituted-1,2-benzisothiazolin-3-ones carrying an aminoalkyl group in the 2-position and being optionally substituted in the 4- and/or 5-position are antithrombotic agents. The compounds, of which 2-(2-diethylaminoethyl)-4,5-dimethyl-1,2-benzisothiazolin-3-one is a representative embodiment, can be prepared by cyclization of an appropriately substituted bis-[2-(aminoalkylcarbamyl)phenyl]disulfide, or by other disclosed methods.

REFERENCES:
patent: 3227715 (1966-01-01), Bub
patent: 3965107 (1976-06-01), Rainey et al.
patent: 3982007 (1976-09-01), Laber et al.
patent: 4113728 (1978-09-01), Baggaley
Fischer, R. et al., Arzneimittel Forsch, 14 (12), pp. 1301-1306 (1964).

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