Anti-thrombogenic, anti-microbial compositions containing hepari

Drug – bio-affecting and body treating compositions – Dentifrices – Organic sulfate or sulfonate containing

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424 9464, 514 2, 514 12, 514196, 514197, 514201, 514209, 530830, 536 21, 523112, A61K 3174, A61K 37547, A61K 31725, A01N 3718

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active

050698990

ABSTRACT:
Anti-thrombobenic, anti-microbial compositions containing heparin reacted with quaternary ammonium components and bound with water-insoluble polymers are disclosed. Such compositions may also contain additional quaternary ammonium compounds not reacted with heparin and may also contain quaternary ammonium compound(s) reacted with antibiotics.

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Gott, V. L., J. D. Whiffen & R. C. Dutton: Heparin Bonding on Colloidal Graphite Surfaces-Science 1.12:1297, 1963.
Gott, V. L., J. D. Whiffen, D. E. Koepke, R. L Daggert, W. C. Boake & W. P. Yang, Techniques of Applying a Graphite-Benzal Kanium-Heparin Coating to Various Plastics & Metals, Trans. Amer. Svc. Artif. Intern. Organs. 10:213, 1964.
Grade G. A., S. J. Anderson, H. M. Giotta & R. D. Falb: Non-Thrombogenic Materials via a Simple Coating Process: Trans. Amer. Soc. Artif. Ioter Organs 15:1, 1969.
Amplatz, K.: A Simple Non-Thrombogenic Coating Invest. Ratl. Jul.-Aug., 1971, vol. 6, pp. 280-289.

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