Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1992-02-26
1994-10-18
Hill, Jr., Robert J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530324, A61K 3702, C12N 1500
Patent
active
053568753
ABSTRACT:
The present invention relates to anti-thrombin polypeptides isolated from the leech Hirudinaria manillensis and to processes for their preparation.
The polypeptides of the invention may be modified by way of amino acid extension at either or each end, and may be subjected to post-translational modification.
The anti-thrombin polypeptides may be prepared by isolating them from the tissue or secretions of the leech Hirudinaria manillensis but they also may be synthetized by recombinant DNA methods.
According to this latter aspect, the invention provides DNA sequences, expression vectors and host cell lines for the recombinant preparation of the polypeptides.
The anti-thrombin polypeptides of the invention find an useful application in the treatment of venous thrombosis, vascular shunt occlusion and thrombin-induced disseminated intravascular coagulation.
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du Poet Philippe de Taxis
Nitti Giampaolo
Sarmientos Paolo
Scacheri Emanuela
Allen Marianne Porta
Farmitalia Carlo Erba S.r.l.
Hill Jr. Robert J.
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