Anti-thrombin polypeptides

Details Anti-thrombin polypeptides Anti-thrombin polypeptides

1994-06-23

1995-08-08

Wax, Robert A.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 691, 4352523, 4353201, 514 2, 530324, 536 221, 536 231, 536 235, C12N 500, C12P 2106, A61K 3702, C07H 1900

Patent

active

054398207

ABSTRACT:
The present invention relates to anti-thrombin polypeptides isolated from the leech Hirudinaria manillensis and to processes for their preparation. The polypeptides of the invention may be modified by way of amino acid extension at either or each end, and may be subjected to post-translational modification. The anti-thrombin polypeptides may be prepared by isolating them from the tissue or secretions of the leech Hirudinaria manillensis but they also may be synthetized by recombinant DNA methods. According to this latter aspect, the invention provides DNA sequences, expression vectors and host cell lines for the recombinant preparation of the polypeptides. The anti-thrombin polypeptides of the invention find an useful application in the treatment of venous thrombosis, vascular shunt occlusion and thrombin-induced disseminated intravascular coagulation.

REFERENCES:
patent: 5268296 (1993-12-01), Maschler et al.

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