Anti-spasmodic agents having a heterocyclic ring

Details Anti-spasmodic agents having a heterocyclic ring Anti-spasmodic agents having a heterocyclic ring

1987-09-10

1989-08-15

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142275, 5142392, 5142395, 514255, 514256, 514277, 514299, 514304, 514305, 514383, 514400, 514406, 514428, A61K 3140, A61K 31495, A61K 31535, A61K 3154

Patent

active

048575356

ABSTRACT:
A new method of treating a patient suffering from smooth muscle spasms involves treatment with a class of anti-spasmodic thioester compounds having a heterocyclic ring containing the nitrogen atom of a secondary or tertiary amine or a bicycloheterocyclic ring system containing the nitrogen atom of a secondary or tertiary amine. These compounds have the general formula I ##STR1## wherein: n is an integer from 0 to 2;

REFERENCES:
patent: 2390555 (1945-12-01), Richardson
patent: 4432977 (1984-02-01), Davis
Compte Rendue de la Societe de Biologie, 140, pp. 477-479, (1946), Dupre, Levy and Tchoubar.
Bulletin de la Societe Chimique, pp. 792-794, (1947), Tchoubar and Letellier-Dupre.
Farmakol i. Toskikol., pp. 10-17, (1956), Liberman with translation.
C. A. Buehler et al., Journal of Medicinal Chemistry 6, pp. 230-233, (1963).
C. A. Buehler et al., Journal of Medicinal Chemistry, vol. 8, p. 643, (Sep. 1965).
R. O. Clinto et al., Journal of the American Chemical Society, 68, pp. 2076-2077, (1946).
Goodman and Gilman, "The Pharmacological Basis of Therapeutics", 6th Ed., MacMillan Publishing Company, Inc., pp. 132 and 134.

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