Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-01-09
2007-01-09
Solola, Taofiq (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S448000, C514S461000
Reexamination Certificate
active
10725935
ABSTRACT:
The provides compounds for the treatment of sickle-cell disease. In particular, the invention provides 5-membered heterocyclic anti-sickling agents that are highly effective and non-toxic, and methods for their use. The compounds include analogues and derivatives of naturally occurring occurring 5-hydroxymethyl-2-furfuraldehyde, 5-Ethyl-2-furfuraldehyde, 5-Methyl-2-furfuraldehyde, and 2-furfuraldehyde, and prodrug forms of the compound.
REFERENCES:
patent: 4987132 (1991-01-01), Mase
patent: 6300332 (2001-10-01), Chang et al.
Zaugg et al., J. Biol. Chem. (1977), vol. 252, No. 23, pp. 8542-8548.
Abraham Donald J.
Burnett James C.
Danso-Danquah Richmond
Joshi Gajanan S.
Musayev Faik N.
Jain Mishrilal
Solola Taofiq
Whitam Michael
Xechem International, Inc.
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