Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-12-28
1997-11-04
Campell, Bruce R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 245, 536 253, A61K 4800, C07H 2104
Patent
active
056839880
ABSTRACT:
The present invention relates to an anti-sense oligodeoxynucleotide to mRNA for one of major fibrogenic cytokines, TGF-.beta., which is secreted in large quantities in wound portion and then stimulates the fibrinoid degeneration of the tissue. The anti-sense oligodeoxynucleotide according to the present invention is complementarily bound to mRNA of TGF-.beta. to inhibit the genetic expression thereof and thus can inhibit the scarring due to the production of fibrogenic cytokines and the fibrinoid degeneration at the wound portion to treat the wound portion so as to have an appearance substantially identical to the normal tissue. Accordingly, the present invention also relates to the use of anti-sense oligodeoxynucleotide to TGF-.beta. as a scarring inhibitor.
REFERENCES:
"Immunohistochemical Localization of Growth Factors in Fetal Wound Healing", D.J. Whitby et al., Dev. Biolo. 147: pp. 207-215, 1991.
"Control of Scarring in Adult Wounds By Neutralizing Antibody to Transforming Growth Factor", M. Shah et al., Lancet 339, pp. 213-214, 1992.
"Transforming Growth Factor-.beta. in Disease: The Dark Side of Tissue Repair", W.A. Border et al., J. Clin. Invest. 90: pp. 1-7, 1992.
"IFN-.pi. Induces the Expression of the Genes For MHC Class II I=A.beta. and Tumor Necrosis Factor Through 1 Protein Kinase C-Independent Pathway", Antonio Celada et al., Journal of Immunology 146, pp. 114-120, 1991.
"Tumor Necrosis Factor-.alpha.-Dependent Production of Reactive Nitrogen Intermediates Mediates IFN-.pi. Plus IL-2-Induced Murine Macrophage Tumoricidal Activity", G.W. Cox et al., Journal of Immunology 149, pp. 3290-3296, 1992.
"Release of Reactive Nitrogen Intermediates and Reactive Oxygen Intermediates from Mouse Peritoneal Macrophages", Aihao Ding et al, Journal of Immunology 141, pp. 2407-2412, 1988.
Campell Bruce R.
Il-Yang Pharm. Co., Ltd.
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