Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Reexamination Certificate
2000-06-01
2003-07-29
Padmanabhan, Sreeni (Department: 1619)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
C514S506000, C514S529000, C514S546000, C514S549000, C514S846000, C514S873000, C424S401000, C424S060000
Reexamination Certificate
active
06599936
ABSTRACT:
FIELD OF THE INVENTION
Cosmetic skin care compositions containing branched esters for controlling sebum/oil on human skin and improving or preventing the appearance of aged skin.
BACKGROUND OF THE INVENTION
Cosmetic products which improve the appearance of skin are increasingly popular with consumers. Frequently, consumers seek to alleviate or delay the signs of aged or photoaged skin, such as fine lines and wrinkles, dry and sagging skin. Consumers also seek other benefits in addition to anti-aging.
A frequent, undesirable skin condition is “oily skin,” the condition which results from the excessive amount of sebum on the skin. Sebum is skin oil which is produced by sebocytes (cells of the sebaceous glands in the skin) and is then secreted to the skin surface. Oily skin is associated with a shiny, undesirable appearance and a disagreeable tactile sensation. Oily skin affects various age groups. Cosmetic products which provide both sebum control and anti-aging benefits are highly desirable.
Several patents disclose the use of branched alcohols in cosmetic compositions. See for instance U.S. Pat. No. 4,496,536 (Moller et al.), U.S. Pat. No. 5,093,112 (Birtwistle et al.), and U.S. Pat. No. 5,344,850 (Hata et al.).
Unfortunately, alcohols, whether branched or not, have a sharp unpleasant odor and thus present a formulation challenge for a cosmetic chemist. The esterification of alcohols changes their odor, but not necessarily for the better.
Cosmetic compositions containing branched esters are also known. U.S. Pat. No. 5,489,426 (Zabotto et al.) describes cosmetic composition containing branched alkyl esters, wherein the branched hydrocarbon chain contains from 3 to 20 carbon atoms. U.S. Pat. No. 5,578,299 (Starch) describes cosmetic rinse-off compositions containing 49-98% of mineral oil and, optionally, a branched chain alcohol ester as an emollient. U.S. Pat. No. 5,658,580 (Mausner) describes anti-sebum compositions containing selected neopentanoate esters to smooth the skin. U.S. Pat. No. 5,773,015 (Bajor et al.) describes anti-sebum compositions containing C11-C30 esters of salicylic acid. U.S. Pat. No. 5,849,273 (Bonda et al.) describes a sunscreen composition containing an alkyl salicylate ester and, optionally, an alkyl benzoate ester; both esters contain a single-branched alkyl, the branch consisting of butyl, or hexyl or octanoyl alkyl radical.
The present invention is based, at least in part, on the discovery of branched esters that have a pleasant scent and also are effective sebum suppressors. It has been iscovered, as part of the present invention that esters of straight chain alcohols are not effective and that not all branched chain alcohol esters are either effective or have a pleasant scent.
SUMMARY OF THE INVENTION
The present invention includes a skin care cosmetic composition comprising:
(i) from about 0.001% to about 50% of a branched chain ester RCOOR′, wherein R is selected from the group consisting of CH
3
, phenyl, and CH
3
(CH
2
)
4
CH═CHCH
2
CH═CH(CH
2
)
7
; and R′ is a methyl-branched hydrocarbon radical containing a total of at least 6 carbons, provided that if R′ contains more than 6 carbons total, the branched ester contains more than one methyl group; and
(ii) a cosmetically acceptable vehicle.
The present invention also includes a method of controlling or preventing an oily skin condition, especially in the facial area, by applying to the skin a composition from about 0.001% to about 100% of the branched ester as described above.
The invention also includes a cosmetic method of reducing, preventing or controlling sebum secretion from sebocytes by applying a composition comprising from about 0.001% to about 100% of the branched ester.
The invention also includes a cosmetic method of stimulating collagen and glycosaminoglycan synthesis by fibroblasts in the skin, by applying a composition comprising from about 0.001% to about 100% of the branched ester.
The invention also includes a cosmetic method of treating or delaying chronoaged, photoaged, dry, lined or wrinkled skin, shielding the skin from harmful UVA and UVB light (sunscreening), increasing stratum corneum firmness and flexibility, and generally increasing the quality of skin by applying to the skin the inventive composition.
The inventive methods and compositions provide control of sebum secretion from sebocytes, improved oil control and improved skin feel, prevent shine and stickiness, while also providing anti-aging benefits which results in reduced appearance of wrinkles and aged skin, improved skin color, treatment of photoaged skin, improvement in skin's radiance and clarity and finish, and an overall healthy and youthful appearance of the skin.
DETAILED DESCRIPTION OF THE INVENTION
Except in the operating and comparative examples, or where otherwise explicitly indicated, all numbers in this description indicating amounts of material or conditions of reaction, physical properties of materials and/or use are to be understood as modified by the word “about.” All amounts are by weight of the oil-in-water emulsion, unless otherwise specified.
The term “skin” as used herein includes the skin on the face, neck, chest, back, arms, hands and scalp.
The inventive methods and compositions include a branched chain ester RCOOR′ wherein R is selected from the group consisting of: (acetate esters), phenyl (benzoate esters), and CH
3
(CH
2
)
4
CH═CHCH
2
CH═CH(CH
2
)
7
(linoleate esters); and R′ is a branched aliphatic hydrocarbon radical containing a total of at least 6 carbon atoms and containing solely methyl branches, provided that if R′ contains more than 6 carbons total, the branched ester contains more than 1 methyl group.
Preferably R′ contains from 6 to 20 carbons, most preferably from 10 to 13 carbons, to attain optimum efficacy. The preferred esters are selected from linoleate esters due to their optimum performance.
The alcohol, which serves as a starting material for the ester, may contain a mix of various chain lengths' alcohols and various branches. Such mixed alcohol is suitable for use in the present invention, as long as the predominant alcohol in the mix contains a total of at least 6 carbon atoms and methyl branching
The ester is employed in the inventive methods in an amount of from 0.001% to about 100%, preferably from 0.1% to 20%, most preferably from 0.1% to 10%.
The branched esters within the scope of the invention are commercially available, e.g. from Exxon (under Exxate® trademark) or may be synthesized in accordance with the procedures in Example 1.
The preferred inventive compositions and methods also include an oil-absorbing powder. Examples of suitable oil-absorbing powder include but are not limited to silica (preferably fumed), talcum, and clay. The preferred oil-absorbing powder is fumed silica, due to its superior oil-absorbing capacity.
The oil-absorbing powder provides an immediate sebum control, but not a long-term relief, since it cannot be used in large amounts without whitening the skin. According to the present invention, the oil-absorbing powder may be present in an amount of no greater than 1%, generally from 0.01% to 1%, preferably from 0.1% to 1%, most preferably from 0.5% to 1%.
Although the branched esters employed in the inventive methods and compositions are liquid, and thus the invention is effective even in the absence of the carrier, the compositions according to the invention comprise a cosmetically acceptable vehicle to act as a diluant, dispersant or carrier for branched ester so as to facilitate their distribution when the composition is applied to the skin.
The vehicle may be aqueous, anhydrous or an emulsion. Preferably, the compositions are aqueous or an emulsion, especially water-in-oil or oil-in-water emulsion. Water when present will be in amounts which may range from 5 to 99%, preferably from 40 to 90%, optimally between 60 and 90% by weight.
Besides water, relatively volatile solvents may also serve as carriers within compositions of the present invention. Most pr
Bajor John
Habif Stephan Samuel
Palanker Laura Rose
Plotkin Ellen
Unilever Home & Personal Care USA , division of Conopco, Inc.
Willis Michael A.
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