Anti-ribonucleotide reductase R2 subunit monoclonal antibody

Details Anti-ribonucleotide reductase R2 subunit monoclonal antibody Anti-ribonucleotide reductase R2 subunit monoclonal antibody

1996-02-07

1999-03-23

Scheiner, Toni R.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Animal cell, per se, expressing immunoglobulin, antibody, or...

435330, 435332, 435338, 435 71, 435 721, 435 723, 5303882, 53038826, 5303888, 53038885, C07K 1618, C12N 512, G01N 3353

Patent

active

058858300

ABSTRACT:
An anti-ribonucleotide reductase (RNR) R2 subunit monoclonal antibody KM1054, KM1056 or KM1060, which belongs to the IgG2a subclass, reacts with R2 subunit of RNR, and inhibits RNR activity, is disclosed. It is effective for immunologically detecting RNR and for immunologically detecting the presence of human cancer cells.

REFERENCES:
Biochemistry, vol. 25, No. 4, 1986, pp. 860-867, A. Anderson, et al., "Production and characterization of monoclonal antibodies against two subunits proteins B1 and B2 of Escherichia Coli Ribonucleotide reductase".
Biochemistry and Cell Biology, vol. 70, 1992, pp. 1081-1087, R.A.R. Hurta & J.A. Wright, "regulation of mammalian ribonucleotide reductase by tumor promoters and protein phosphatase inhibitors okadaic acid and calyculin A".
J. Clin. Invest., vol. 87, 1991, pp. 519-527, D.L.M. Tay et al., "Quantitation of G0 and G1 phase cells in primary carcinomas".
International Journal of Oncology, vol. 6, Mar. 1995, pp. 523-529, T. Saeki, et al., "Immunohistochemical detection of ribonucleotide reductase in human breast tumors".
Thelander, et al., "Reduction of Ribonucleotides", Annu. Rev. Biochem.; vol. 48, pp. 133-158 (1979).
Eriksson, et al., "Ribonucleotide Reductase in Cultured Mouse Lymphoma Cells", The Journal of Biological Chemistry, vol. 256 No. 18, pp. 9436-9440 (1981).
Engstrom, et al., "Immunocytochemical evidence for the cytoplasmic localization and differential expression during the cell cycle of the M1 and M2 subunits of mammalian ribonucleotide reductase", The EMBO Journal, vol. 7, No. 6, pp. 1615-1620 (1988).
Yano, et al., Inhibition of Histamine Secretion by Wortmannin through the Blockade of Phosphatidylinositol 3-Kinase in RBL-2H3 Cells, Journal of Biological Chemistry, vol. 268, No. 34, pp. 25846-25856 (1993).
Takeda, et al., "Role of Ribonucleotide Reductase in Expression of the Neoplastic Program", Life Sciences, vol. 28, pp. 1007-1014 (1981).
Streeper, et al., "A Rapid Assay for CDP Reductase Activity in Mammalian Cell Extracts", Analytical Biochemistry, vol. 34, pp. 123-130 (1970).
Engstrom, "Monoclonal Antibodies Against Mammalian Ribonucleotide Reductase", Acta Chemica Scandinavia, vol. B36, No. 5, pp. 343 and 344.
Cosentino et al, Biochem Cell Biol 69:79-83, 1991.

Affiliated with

Also associated with

Rating

Anti-ribonucleotide reductase R2 subunit monoclonal antibody does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-ribonucleotide reductase R2 subunit monoclonal antibody, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-ribonucleotide reductase R2 subunit monoclonal antibody will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2124320