Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ortho-hydroxybenzoic acid or derivative doai
Patent
1991-04-23
1993-03-09
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ortho-hydroxybenzoic acid or derivative doai
514162, 514165, 5142265, 514356, 514365, 514375, 514404, 514419, 514420, 514423, 514428, 514429, 514448, 514567, 514569, 514570, A61K 3160, A61K 31615, A61K 3154, A61K 3144, A61K 31425, A61K 3142, A61K 31415, A61K 3140, A61K 3138, A61K 31195, A61K 3119
Patent
active
051927535
ABSTRACT:
This invention pertains to the novel use of anti-rheumatoid arthritic drugs in the treatment of dementia. A method of treating dementia in human beings which comprises administering to the human being a therapeutic amount of a non-steroidal anti-inflammatory drug (NSAID) which has the ability to inhibit prostaglandin synthesis in the human being.
REFERENCES:
Martindale, The Extra Pharmacopoeia, 28th Ed. (1982) pp. 234-282.
W. N. Kelley, E. D. Harris, Jr., S. Ruddy, and C. B. Sledge, "The Textbook of Rheumatology", 1989 W. B. Saunders Company.
D. A. Evans, H. H. Funkenstein, and M. S. Albert et al. "Prevalence of Alzheimer disease in a community population of older Persons", JAMA 1989; 262: 2551-2556.
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R. Sulkava, J. Wikstrom, A. Aromaa et al., "Prevalence of Severe Dementia in Finland", Neurology 1985; 35: 1025-1029.
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J. Rogers, J. Luber-Narod, S. D. Styren, and W. H. Civin, "Expression of Immune System-Associated Antigens By Cells of the Human Central Nervous System: Relationship to the Pathology of Alzheimer's Disease" Neurobiology of Aging, 1988, vol. 9. 339-349.
P. L. McGeer, H. Akiyama, S. Itagaki, and E. G. McGeer, "Immune System Response in Alzheimer's Disease", The Canadian Journal of Neurological Sciences 1989; 16: 516-527.
P. L. McGeer, H. Akiyama, S. Itagaki and E. G. McGeer, "Activation of the Classical Complement Pathway in Brain Tissue of Alzheimer Patients", Neuroscience Letters 1989; 107: 341-346.
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McGeer Edith
McGeer Patrick L.
Rogers Joseph
Sibley John
Henley III Raymond J.
Waddell Frederick E.
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