Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1990-11-02
1992-04-14
Nutter, Nathan M.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 23, 536 24, 536 26, 536 27, 536 28, 536 29, 514 44, 514 46, 514 47, 514 48, 514 49, 514 50, 514 51, A61K 3170, A61K 900, A61K 922
Patent
active
RE0338877
ABSTRACT:
A-B-C wherein A and C are each independently 2',3'dideoxynucleosides and B is a linking group; and a method of treating or preventing a retroviral injection in a subject by administering the compounds of the invention.
REFERENCES:
patent: 4724232 (1988-02-01), Rideout et al.
Broder, AIDS, Modern Concepts and Therapeutic Challenges; 303-333, 1987, Marcel Dekker, Inc., New York.
Mitsuya and Broder, Strategies for Antiviral Therapy in AIDS, Nature, vol. 325, No. 6017, Feb. 1987, 773-778.
Yarchoan and Broder, Special Report: Development of Anti-Retroviral Therapy for the Acquired Immunodeficiency Syndrome and Related Disorder, New England Journal of Medicine, vol. 316, Feb. 26, 87, 557-564.
Dahlberg et al., Broad Spectrum Anti-Retroviral Activity of 2',3'-dideoxynucleosides, Proceedings of the National Academy of Sciences, U.S.A., vol. 84 (1987), pp. 2469-2473.
Mitsuya et al., 3'-Azido-3'-Deoxythymidine: An Antiviral Agent that Inhibits the Infectivity and Cytopathic Effect of Human T-Lymphotropic Virus Type III/Lymphadenopathy-Associated Virus in Vitro, Proceedings of the National Academy of Sciences, U.S.A., vol. 82, Oct. 1985, 7096-7100.
Wapar et al., Effects of 2',3'-Dideoxynucleosides on Mammalian Cells and Viruses, Journal of Cellular Physiology 121: 402-408 (1984).
Busso et al., "Nucleotide Dimers Suppress HIV Expression in Vitro", AIDS Research and Human Retroviruses, vol. 4, No. 6 (1988), pp. 449-455, Appendix I.
Broder Samuel
Mitsuya Hiroaki
Tam Steve
Weigele Manfred
Epstein William H.
Gould George M.
Hoffmann-La Roche Inc.
Nutter Nathan M.
Pokras Bruce A.
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