Anti-protozoan methods and materials

Details Anti-protozoan methods and materials Anti-protozoan methods and materials

1997-07-07

2000-01-11

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514944, 514937, 424 45, 424405, 424DIG12, A61K 3800

Patent

active

060136294

ABSTRACT:
The present invention relates to methods for treating protozoan infections comprising administering to a subject suffering from protozoan infection, a bacteriocidal/permeability-inducing (BPI) protein product.

REFERENCES:
patent: 5089274 (1992-02-01), Marra et al.
patent: 5171739 (1992-12-01), Scott
patent: 5198541 (1993-03-01), Elsbach et al.
patent: 5217956 (1993-06-01), Zasloff et al.
patent: 5234912 (1993-08-01), Marra et al.
patent: 5308834 (1994-05-01), Scott et al.
patent: 5334584 (1994-08-01), Scott et al.
patent: 5348942 (1994-09-01), Little, II et al.
patent: 5646114 (1997-07-01), Lambert, Jr.
Araujo et al., "In Vitro and In Vivo Activities of the Hydroxynaphthoquinone 566C80 Against the Cyst Form of Toxoplasma gondii", Antimicrobial Agents Chemotherapy, 36(2):326-330 (Feb. 1992).
Araujo et al., "Remarkable In Vitro and In Viro Activities of the Hydroxynaphthoquinone 566C80 Against Tachyzoites and Tissue Cysts of Toxoplasma gondii", Antimicrobial Agents Chemotherapy, 35(2):293-299 (Feb. 1991).
Butcher et al., "Heparin Enhances the Interaction of Infective Leishmania donovani Promastigotes with Mouse Peritoneal Macrophages", J. Immunol., 148(9):2879-2886 (May 1, 1992).
Butcher et al., "Leishmania donovani: Cell-Surface Heparin Receptors of Promastigotes are Recruited from an Internal Pool after Trypsinization", Experimental Parasitology, 71:49-59 (1990).
Eliopoulos and Moellering, "Antimicrobial Combinations", in Antibiotics in Laboratory Medicine, 3rd ed., pp. 432-492, (Lorian ed., Baltimore, MD) (1991).
Elsbach, "Antibiotics from Within: Antibacterials from Human and Animal Sources", Trends. Biotech, 8(1):26-30 (Jan. 1990).
Elsbach and Weiss, "Oxygen-Independent Antimicrobial Systems of Phagocytes," in Inflammation: Basic Principles and Clinical Correlates, pp. 603-636, (Gallin et al eds., Raven Press, Ltd.) (1992).
Elsbach and Weiss, "Oxygen-Independent Bactericidal Systems of Polymorphonuclear Leukocytes", in Advances in Inflammation Research, vol. 2, pp. 95-113 (Weissmann ed., Raven Press, Ltd.) (1981).
Elsbach et al., "Separation and Purification of a Potent Bactericidal/Permability-Increasing Protein and a Closely Associated Phospholipase A.sub.2 from Rabbit Polymorphonuclear Leukocytes", J. Biol. Chem., 254(21):11000-11009 (Nov. 10, 1979).
Gabay, "Ubiquitous Natural Antibiotics", Science, 264:373-374 (Apr. 15, 1994).
Gazzano-Santoro et al., "High-Affinity Binding of the Bactericidal/Permeability-Increasing Protein and a Recombinant Amino-Terminal Fragment to the Lipid A Region of Lipopolysaccharide", Infect. Immun., 60(11):4754-4761 (Nov. 1992).
Gray et al., "Cloning of the cDNA of a Human Neutrophil Bactericidal Protein", J. Biol. Chem., 264(16):9505-9509 (Jun. 5, 1989).
Hunter et al., "Cytokine mRNA in the Central Nervous System of SCID Mice Infected with Toxoplasma gondii: Importance of T-Cell-Independent Regulation of Resistance to T. gondii", Infect. Immun., 61(10):4038-4044 (Oct. 1993).
Levy et al., "Antobacterial 15-kDa Protein Isoforms (p15s) are Members of a Novel Family of Leukocyte Proteins", J. Biol. Chem., 268(8):6058-6068 (Mar. 16, 1993).
Mannion et al., "Preferential Binding of the Neutrophil Cytoplasmic Granule-Derived Bactericidal/Permeability-Increasing Protein to Target Bacteria", J. Clin. Invest., 142(8):2807-2812 (Apr. 15, 1989).
Mannion et al., "Separation of Sublethal and Lethal Effects of Polymorphonuclear Leukocytes on Escherichia coli", J. Clin. Invest., 86:631-641 (Aug. 1990).
Mannion et al., "Separation of Sublethal and Lethal Effects of the Bactericidal/Permeability Increasing Protein on Escherichia coli", J. Clin. Invest., 85:853-860 (Mar. 1990).
Mukhopadhyay et al., "Heparin Binds to Leishmania donovani Promastigotes and Inhibits Protein Phosphorylation". Biochem. J., 264:517-525 (1989).
Ooi et al., "A25-kDa NH.sub.2 -terminal Fragment Carries All the Antibacterial Activities of the Human Neutrophil 60-kDa Bactericidal/Permeability-Increasing Protein", J. Biol. Chem., 262(31):14891-14894 (1987).
Ooi et al., Endotoxin-neutralizing Properties of the 25 kD N-Terminal Fragment and a Newly Isolated 30 kD C-Terminal Fragment of the 55-60 kD Bactericidal/Permeability-Increasing Protein of Human Neutrophils, J. Exp. Med., 174:649-655 (Sep. 1991).
Ooi et al. "Isolation of Two Isoforms of a Novel 15-kDa Protein from Rabbit Polymorphonuclear Leukocytes that Modulate the Antibacterial Actions of Other Leukocyte Proteins", J. Biol. Chem., 265 (26):15956-15962 (Sep. 15, 1990).
Ortega-Barria et al., "A Novel T. Cruzi Heparin-Binding Protein Promotes Fibroblast Adhesion and Penetration of Engineered Bacteria and Trypanosomes into Mammalian Cells", Cell, 67:411-421 (Oct. 18, 1991).
Veld et al., "Effects of the Bactericidal/Permeability-Increasing Protein of Polymorphonuclear Leukocytes on Isolated Bacterial Cytoplasmic Membrane Vesicles", Infect. Immun., 56(5):1203-1208 (May 1988).
Weiss and Olsson, "Cellular and Subcellular Localization of the Bacterial/Permeability-Increasing Protein of Neutrophils", Blood, 69(2):652-659 (Feb. 1987).
Weiss et al., "Human Bactericidal/Permeability-Increasing Protein and a Recombiant NH.sub.2 -Terminal Fragment Cause Killing of Serum-resistant Gram-negative Bacteria in Whole Blood and Inhibit Tumor Necrosis Factor Release Induced by the Bacteria", J. Clin. Invest., 90:1122-1130 (Sep.1992).
Weiss et al., "Resistance of Gram-negative Bacteria to Purified Bactericidal Leukocyte Proteins", J. Clin. Invest., 65:619-628 (Mar. 1980).
Weiss et al., "The Role of Lipopolysaccharides in the Action of the Bactericidal/Permeability-Increasing Neutrophil Protein on the Bacterial Envelope", J. Immunol., 132(6):3109-3115 (Jun. 1984).
Little et al., "Functional Domains of Recombiant Bactericidal/Permeability Increasing Protein (rBPI-23)", J. Biol. Chem., 269(3):1865-1872 (Jan. 21, 1994).
PCT International Preliminary Examination Report for PCT/US95/08624 dated Nov. 7, 1996.

Affiliated with

Also associated with

Rating

Anti-protozoan methods and materials does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-protozoan methods and materials, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-protozoan methods and materials will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1462410