Anti-protozoal oxadiazole derivatives

Details Anti-protozoal oxadiazole derivatives Anti-protozoal oxadiazole derivatives

1979-07-12

1981-10-13

Sutto, Anton H.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548131, A61K 3142, C07D27106

Patent

active

042948436

ABSTRACT:
Anti-protozoal 1,2,4-oxadiazole derivatives of the formula: ##STR1## wherein R.sup.1 is amino or substituted amino; each R.sup.2 is the same or different in one or more of the 3, 4, 5 or 6 positions and is hydrogen, lower alkyl, halogen, hydroxy, alkoxy, alkylthio, arylthio, amino, substituted amino, cyano or nitro; X and Y together represent a bond or X and Y are both hydrogen; R.sup.3 is hydrogen, lower alkyl, aryl, substituted aryl or ArS.CH.sub.2 --; and Ar is unsubstituted or mono-, di- or tri-substituted phenyl wherein the substituents may be the same of different, and acid addition salts thereof, methods for their preparation, formulations thereof and their use in the treatment of protozoal infections, especially malaria are described.

REFERENCES:
patent: 3897447 (1975-07-01), Fisher et al.
patent: 4067988 (1978-01-01), Buret et al.
patent: 4148801 (1979-04-01), Santilli et al.
Rochling, et al., "Liebigs Ann. Chem.", 1974, 504-522.
Jaunin, "Chem. Abst.", vol. 64, (1966), p. 11197.
Derwent Abstract 81163X/44 and Othen.
Haynes et al., "J. Med. Chem.", vol. 15, No. 11, (1972), pp. 1198-2000.

Affiliated with

Also associated with

Rating

Anti-protozoal oxadiazole derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-protozoal oxadiazole derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-protozoal oxadiazole derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-931035