Anti-protozoal oxadiazole derivatives

Details Anti-protozoal oxadiazole derivatives Anti-protozoal oxadiazole derivatives

1979-07-12

1981-10-13

Sutto, Anton H.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548131, A61K 3142, C07D27106

Patent

active

042948428

ABSTRACT:
Anti-protozoal 1,2,4-oxadiazole derivatives of the formula ##STR1## where R.sup.1 is hydrogen, lower alkyl, halogen, hydroxy, alkoxy or nitro; each R.sup.2 is the same or different in one or more of the 3,4,5 or 6 positions and is hydrogen, lower alkyl, halogen, hydroxy, aryloxy, alkylthio, arylthio, amino, substituted amino, cyano or nitro or two adjacent groups R.sup.2 together form a residue --CH.dbd.CH--CH.dbd.CH--; or R.sup.1 and one R.sup.2 together form a residue --CH.dbd.CH--CH.dbd.CH--; R.sup.3 is hydrogen, lower alkyl, aryl, substituted aryl or a group Ar SCH.sub.2 - were Ar is an unsubstituted or mono, di-or-tri- substituted phenyl group where the substituents are the same or different; and X and Y together form a bond or are each hydrogen; and acid addition salts thereof, methods for their preparation, formulations thereof and their use in the treatment of protozoal infections are described.

REFERENCES:
patent: 3897447 (1975-07-01), Fisher et al.
patent: 4067988 (1978-11-01), Buret et al.
Jaunin, "Chem. Abs.", vol. 64, (1966), p. 11197.
Haynes et al., "J. Med. Chem.", vol. 15, No. 11, (1972), pp. 1198-1200.
Derwent Copie of Belgium Pat. No. 840,719, and U.S. Pat. No. 3,907,807.

Affiliated with

Also associated with

Rating

Anti-protozoal oxadiazole derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-protozoal oxadiazole derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-protozoal oxadiazole derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-931032