Anti-proliferative and anti-inflammatory compounds: 5- or 6-deox

Details Anti-proliferative and anti-inflammatory compounds: 5- or 6-deox Anti-proliferative and anti-inflammatory compounds: 5- or 6-deox

1992-06-29

1994-11-01

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 173, 536 187, 536 41, 514 25, A01N 4304, C07H 1500

Patent

active

053607929

ABSTRACT:
The compounds of this invention are 5- or 6-deoxy hexose monosaccharides having a saturated nitrogen-containing heterocycle at the 5- or 6-position bound through the nitrogen atom. The saturated nitrogen-containing heterocycle substituent is shown by the following formula: ##STR1## where X is CH.sub.2, NH or O; and n ranges from 3-6. These hexose monosaccharides may also be ethereally substituted at least one other position. The compounds exhibit anti-proliferative and anti-inflammatory activity. Methods of preparation, pharmaceutical compositions containing the compounds and methods of treating inflammatory and/or autoimmune disorders employing the compounds are disclosed.

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