Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2007-09-04
2007-09-04
Spector, Lorraine (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S350000, C530S388100, C530S388150, C530S391300
Reexamination Certificate
active
10223088
ABSTRACT:
Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
REFERENCES:
patent: 2004/0048249 (2004-03-01), Tang et al.
patent: WO 02/08284 (2002-01-01), None
patent: WO 02/08284 (2002-01-01), None
patent: WO 02/086443 (2002-10-01), None
Accession No. AL139004(Lovell, J.), Creation Date Feb. 8, 2000.
Accession No. AC007394(Waterston, R. H.), Creation Date Apr. 27, 1999.
Goddard Audrey
Godowski Paul J.
Gurney Austin L.
Stephan Jean-Philippe F.
Watanabe Colin K.
Barnes Elizabeth M.
Dreger Ginger R.
Genentech Inc.
Kresnak Mark T.
Lockard Jon M.
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