Anti-platelet membrane glycoprotein VI monoclonal antibody

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C435S328000, C435S332000, C530S350000, C530S388100, C530S388200, C530S391300

Reexamination Certificate

active

07977461

ABSTRACT:
The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof:a) It specifically binds to human platelet membrane glycoprotein VI (GPVI);b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; andc) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.

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