Anti-platelet aggregating 1,3-oxathiane derivatives, composition

Details Anti-platelet aggregating 1,3-oxathiane derivatives, composition Anti-platelet aggregating 1,3-oxathiane derivatives, composition

1986-05-09

1988-04-05

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549 14, A61K 3139, C07D32706

Patent

active

047359633

ABSTRACT:
The invention concerns novel [5,6]-cis-1,3-oxathiane derivatives of formula I in which R.sup.1 and R.sup.2 are variously defined as hydrogen, alkyl, trifluoromethyl or phenyl (as set out in the specification), n is 1 or 2, m is 2, 3 or 4, Y is vinylene and Z is carboxy, 1(H)-tetrazol-5-yl or a group of the formula --CO.NH.SO.sub.2 R.sup.3 in which R.sup.3 is alkyl, phenyl or benzyl, and pharmaceutically acceptable salts thereof, for use in conjunction with their pharmaceutical compositions in treating certain pulmonary and/or vascular disorders. The invention also describes various processes and intermediates for the manufacture of the novel compounds.

REFERENCES:
Shimoji et al, Chemistry Letters, Chem. Soc. of Japan 1978, pp. 1375-1376.

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