Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2007-12-04
2007-12-04
Duffy, Patricia A. (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C530S350000
Reexamination Certificate
active
10630629
ABSTRACT:
Compositions that inhibit the binding ofPlasmodium falciparumto erythrocytes include a family of erythrocyte binding proteins (EBPs). The EBPs are paralogues of theP. falciparumbinding protein EBA-175. The present invention includes peptides of the paralogues that prevent the binding ofP. falciparum. Antibodies specific for each paralogue that also prevent the binding ofP. falciparumare also included. Methods of the invention utilize the paralogues, antibodies thereof and peptide compositions for the diagnosis, prevention, and treatment ofP. falciparumdiseases such as malaria, as well as methods for the detection ofP. falciparumin biological samples and culture media.
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Narum David L.
Sim Kim L.
Duffy Patricia A.
Knobbe Martens Olson & Bear LLP
The Government of the United States of America, as represented b
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