Drug – bio-affecting and body treating compositions – Dentifrices – Ammonia – amine – or derivative thereof
Patent
1992-02-20
1993-01-26
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Dentifrices
Ammonia, amine, or derivative thereof
424 49, A61K 716, A61K 722
Patent
active
051821010
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to a toothpaste in the form of a dispersion of calcium carbonate as polish in an aqueous carrier which contains an antimicrobial biguanide compound as plaque-inhibiting component and of which the other components are selected according to type and quantity so that plaque formation is optimally inhibited despite a relatively low dosage of the antimicrobial biguanide compound.
2. Statement of Related Art
It has long been known that antimicrobial biguanide compounds are effective in preventing the formation of dental plaque. However, their effect is greatly reduced or even completely eliminated by many of the components typically used in toothpastes, more particularly by certain polishes, such as calcium carbonate for example, and also by many binders and viscosity regulators, surfactants and even by certain sweeteners. Accordingly, there has been no shortage of attempts to find components which do not impair antimicrobial biguanides or which prevent any such impairment. Thus, according to DE-OS 21 58 149 for example, .alpha.-aluminum oxide trihydrate having a certain particle size is used as the polish component. On the other hand, according to DE-OS 34 44 958, certain surfactants enhance the effect of antimicrobial biguanide. However, this effect also is disturbed in the presence of calcium carbonate as polish or in the presence of anionic binders and viscosity regulators, anionic surfactants and solubilizers.
DESCRIPTION OF THE INVENTION
Summary of the Invention
Accordingly, a satisfactory toothpaste which is extremely effective in inhibiting plaque formation, even despite low doses of the antimicrobial biguanide compounds, is not known from the prior art. The problem addressed by the present invention was to solve this problem for toothpastes containing chalk as the polish component. The present invention relates to a toothpaste in the form of an aqueous dispersion containing 10 to 60% by weight of polish, 2 to 20% by weight of humectants, 0.5 to 5% by weight of water-soluble viscosity regulators, 0.05 to 0.5% by weight of antimicrobial biguanides and 1 to 5% by weight of other additives from the group of surfactants, flavoring oils and sweeteners, characterized in that calcium carbon-ate (chalk) is predominantly present as the polish, non-ionic polysaccharide derivatives are present as the viscosity regulators and a cationic surfactant containing a linear C.sub.12-18 alkyl group and one or two tertiary amino groups or quaternary ammonium groups are present as the surfactants, a nonionic solubilizer for the flavoring oil optionally being present.
DESCRIPTION OF PREFERRED EMBODIMENTS
The polish used is preferably a precipitated chalk of which the particles are essentially smaller than 20 .mu.m in diameter, better yet smaller than 10 .mu.m and preferably between 1 and 5 .mu.m.
Suitable humectants are glycerol, sorbitol, propylene glycol and polyethylene glycols, glycerol and/or sorbitol being preferred. Suitable water-soluble viscosity regulators are nonionic polysaccharide derivatives, for example methyl, hydroxyethyl and hydroxypropyl ethers of cellulose, starch, guar, xanthan and vegetable gums. Hydroxyethyl cellulose and methyl hydroxypropyl cellulose are preferably used.
The 1,1'-hexamethylene-bis-{5-(4-chlorophenyl)-biguanide} ("chlorhexidine") known from GB-A-705,838 in the form of a water-soluble, physiologically acceptable salt, for example in the form of the acetate or gluoonate, is used as the antimicrobial biguanide compound. Other antimicrobial biguanide compounds suitable for the purposes of the invention are, for example, 1,1'-hexamethylene-bis-{5-(4-fluorophenyl)-biguanide} ("fluorhexidine"), the polyhexamethylene biguanide compounds of the Vantocil IB (ICI) type known from GB-A-702,268 and the antimicrobial biguanide compounds known from U.S. Pat. Nos. 2,684,924, 2,990,425, 3,468,898, 4,022,834, 4,053,636 and 4,198,392.
Preferred cationic surfactants in the toothpaste according to the invention are those
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Klueppel Hans-Juergen
Lehmann Rudolf
Wuelknitz Peter
Henkel Kommanditgesellschaft auf Aktien
Jaeschke Wayne C.
Rose Shep K.
Szoke Ernest G.
Wisdom, Jr. Norvell E.
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