Anti-p55 TNF receptor antibody

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C530S387100, C530S387300, C530S388220

Reexamination Certificate

active

07728111

ABSTRACT:
A method of modulating signal transduction and/or cleavage in Tumor Necrosis Factor Receptors (TNF-Rs) is provided. Peptides or other molecules may interact either with the receptor itself, or with effector proteins interacting with the receptor, thus modulating the normal functioning of the TNF-Rs. Such peptides or other molecules may be employed for prophylactic and therapeutic applications in TNF associated diseases.

REFERENCES:
patent: 5811261 (1998-09-01), Wallach et al.
patent: 7056505 (2006-06-01), Wallach et al.
patent: 7429379 (2008-09-01), Wallach et al.
patent: 0393438 (1990-10-01), None
patent: 0412486 (1991-02-01), None
patent: 0444560 (1991-09-01), None
Aggarwal BB, “Structure of tumor necrosis factor and its receptor”, Biotherapy 3(2):113-120 (1991).
Carlson, “Anew use for intracellular antibody expression: Inactivation of human immunodeficiency virus type 1”, PNSA USA, 90:7427-7428 (1993).
Engelmann et al, “Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity”, J Biol Chem 265(24):14497-14504 (1990).
Espevik et al, “Characterization of binding and biological effects of monoclonal antibodies against a human tumor necrosis factor receptor”, J Exp Med 171(2):415-426 (1990).
Fitzgerald et al (Eds), The Cytokine Facts Book, Human TNF-R p55 and p75, p. 478 (2001).
Hwang et al, “A 20 amino acid synthetic peptide of a region from the 55 kDa human TNF receptor inhibits cytolytic and binding activities of recombinant human tumour necrosis factor in vitro”, Proc R Soc Lond B Biol Sci 245(1313):115-9 (1991).
Kameyama et al., “Effects of Cell-Permeating Peptide Binding on the Districution of 125I-Labeled Fab Fragments in rats”, Bioconjugate Chem., 17:597-602, (2006).
Kuebler et al., “A novel signaling mechanism between gas and blood compartments of the lung”, J. Clin. Invest., 105:905-913 (2000).
Lie et al, “Identification of the binding site of 55kDa tumor necrosis factor receptor by synthetic peptides”, Biochem Biophys Res Commun 188(2):503-9 (1992) .
Porteau et al, “Human neutrophil elastase releases a ligand-binding fragment from the 75-kDa tumor necrosis factor (TNF) receptor. Comparison with the proteolytic activity responsible for shedding of TNF receptors from stimulated neutrophils”, J Biol Chem 266(28):18846-18853 (1991).
Schwarze et al., “In vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse”, Science, 285:1569-1572 (1999).
Shalaby et al, “Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors”, J Exp Med 172(5):1517-20 (1990).
Sol et al., “Possible Interactions between the NS-1 Protein and Tumor Necrosis factor alpha pathways in Erythroid Cell Apoptosis Induced by Human Parvovirus B19”, Journal of Virology, 73:8762-8770 (1999).

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