Anti-oxidative and anti-inflammatory metal:peptide complexes and

Details Anti-oxidative and anti-inflammatory metal:peptide complexes and Anti-oxidative and anti-inflammatory metal:peptide complexes and

1990-02-09

1992-06-02

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 8, 514 17, 514 18, 530322, 530329, 530330, 530331, C07K 508, C07K 900

Patent

active

051186659

ABSTRACT:
Compositions and methods for enhancing or restoring the resistance of a warm blooded animal to oxidative or inflammatory damage caused be release of reactive oxygen species by certain immune cells and other physiological processes are disclosed. The compositions include metal:peptide and metal:peptide:chelating agent complexes.

REFERENCES:
patent: 3194732 (1965-07-01), Neuhauser
patent: 3551554 (1970-12-01), Herschler
patent: 3558770 (1971-01-01), Gordon et al.
patent: 3758682 (1973-09-01), Huber et al.
patent: 3767784 (1973-10-01), Gluck
patent: 3832338 (1974-08-01), Huber et al.
patent: 4022888 (1977-05-01), Huber et al.
patent: 4167945 (1979-09-01), Gottlieb
patent: 4177261 (1979-12-01), Dietze et al.
patent: 4263428 (1981-04-01), Apple et al.
patent: 4287184 (1981-09-01), Young
patent: 4440788 (1984-04-01), Terayama et al.
patent: 4665054 (1987-05-01), Pickart
patent: 4760051 (1988-07-01), Pickart
patent: 4767753 (1988-08-01), Pickart
Pickart et al., "Growth-Modulating Tripeptide (glycylhistidyllysine): Association with Copper and Iron in Plasma and Stimulation of Adhesive and Growth of Hepatoma Cells in Culture by Tripeptide-Metal Ion Complexes," J. Physiol. 102(2):129-139, 1980.
Williams et al., "Glycyl-L-Histidyl-L-Lysine, a Growth Promoting Factor for Human Cells," Cytobios 27(105):19-25, 1980.
Mochida Pharmaceutical Co., Ltd., "Anti-Inflammatory Injections Containing Superoxide Dismutase," Jpn. Kokai Tokkyo Koho, 81 07,720,27 Jan. 1981 (cited in Chem. Abstracts 94:145386f, 1981).
Kwa, "Glycyl-L-Histidyl-L-Lysine: Synthesis of Analogs and NMR Studies," Ph.D. Thesis, University of Washington, 1983.
Loker, "Synthesis of Blood Serum Peptide Cell Growth Factors," Ph.D. Thesis, University of Washington, 1980.
Pickart, "The Biological Effects and Mechanism of Action of the Plasma Tripeptide Glycyl-L-Histidyl-L-Lysine," Lymphonkines 8:425-446, 1983.
Poole et al., "Stimulation of Rat Peritoneal Mast Cell Migration by Tumor-Derived Peptides," Cancer Research 43:5857-5861, 1983.
Raju et al., "Ceruloplasmin, Copper Ions, and Angiogenesis," JNCI 69(5):1183-1188, 1982.
Freedman et al., "Structure of the Glycyl-L-Histidyl-L-Lysine-Copper(II) Complex in Solution," Biochemistry 21:4540-4544, 1982.
Kwa et al., "PMR Studies of Cu(II) and Zn(II) Interaction with Glycyl-L-Histidyl-L-Lysine and Related Peptides," Peptides: Structure and Function 8:805-808, 1983.
Perkins et al., "The Structure of a Copper Complex of the Growth Factor Glycyl-L-Histidyl-L-Lysine at 1.1 A Resolution," Inorganica Chimica Acta 82:93-99, 1984.
Kimoto et al., "Enhancement of Antitumor Activity of Ascorbate Against Ehrich Ascites Tumor Cells by the Copper: Glycylglycylhistidine Complex," Cancer Research 43:824-828, 1983.
Sorenson, "Copper Complexes: A Physiologic Approach to Treatment of Chronic Diseases," Comprehensive Therapy 11(4):49-64, 1985.
Pickart et al., "Inhibition of the Growth of Cultured Cells and an Implanted Fibrosarcoma by Aroylhydrazone Analogs of the Gly-His-Lys-Cu(II) Complex," Biochem. Pharmacol. 32(24):3868-3871, 1983.
Pickart et al., "Growth-Modulating Plasma Tripeptide May Function by Facilitating Copper Uptake Into Cells," Nature 288:715-717, 1980.
"Newsreport on Use of GGH-Cu(II) and Ascorbic Acid," Natural Healing Annual 1986, p. 38 (M. Bricklin (ed.), Prevention Magazine, Rodale Press, Emmaus, Pa.).
Pickart et al., "A Synthetic Tripeptide which Increases Survial of Normal Liver Cells, and Stimulates Growth in Hepatoma Cells," Biochem. Biophys. Res. Commun. 54(2):562-66, 1973.
Aonuma et al., "Studies on Anti-Ulcerogenic Protein in Inflamed Rabbit Skin Tissues," Yakugaku Zasshi 104(4):362-73, 1984.
Downey et al., "Acceleration of Wound Healing Using GHL-Cu(II)," Surgical Forum 36:573-75, 1985.
Pickart et al., "A Human Plasma Growth Factor with Superoxide Dismutase-like and Wound-healing Properities," Superoxide Dim. Chem., Biol. Med. Proc. Int. Conf. 4th 1985 (Pub. 1986), 555-57. (cited in Chem Abstract 106:13579c).
Frater-Schroder et al., "Tumor Necrosis Factor Type .alpha., a Potential Inhibitor of Endothelia Cell growth in vitro is Angiogenic in vivo," Proc. Natl. Acad. Sci. USA 34:5277-81 (1987).
Pickart, "The use of Glycylhistidyllysine in Culture Systems," In Vitro 17(6):459-466 (1981).

Affiliated with

Also associated with

Rating

Anti-oxidative and anti-inflammatory metal:peptide complexes and does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-oxidative and anti-inflammatory metal:peptide complexes and, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-oxidative and anti-inflammatory metal:peptide complexes and will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2228436