Anti-osteopathic composition

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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514352, A61K 3144, A61K 31195

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active

057031282

ABSTRACT:
An anti-osteopathic composition comprising as an active ingredient a compound represented by the following formula (I), (II) or (III): ##STR1## which is useful for therapeutic and prophylactic treatment of osteopathia such as osteoporosis and bone fracture.

REFERENCES:
patent: 5070108 (1991-12-01), Margolis
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Tamura et al., "Synthetic Retinoids, Retinobenzoic Acids, Am80, Am580 and Ch55 Regulate Morphogenesis in Chick Limb Bud," Cell Differentiation and Development, vol. 32, 1990, pp. 17-26.
Mark et al., "Effects of Retinoids on Tooth Morphogenesis and Cytodiffrentiations, in vitro," Int. J. Dec. Biol. vol. 36, 1992, pp. 517-526.
Oikawa et al., "Three Novel Synthetic Retionoids, Re80, Am580 and Am80, All Exhibit Anti-Angiogenic Activity In Vivo," European Journal of Pharmacology, vol. 249, 1993, pp. 113-116.
Gianni et al., "Effects of Synthetic Retinoids and Retinoic Acid Isomers on the Expression of Alkaline Phosphatase in F9 Teratocarcinoma Cells," Biochemical and Biophysical Research Commnications, vol. 196, No. 1, 1993, pp. 253-259.
Pharmaceutical Sciences (1980), 10th Edition, pp. 420-427.
Chemical Abstracts, vol. 108, No. 37406m, Shrott et al. (1988).
Chemical Abstracts, vol. 122, No.290715p, Fenton et al.(1995), 03 Feb. 1994 .

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