Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1990-09-27
1995-05-09
Hutzell, Paula K.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303882, 43524027, 4351722, 435 7021, C07K 1528, C12N 520, C12N 1502, C12P 2108
Patent
active
054140722
ABSTRACT:
The invention relates to a monoclonal antibody which binds to octopus rhodopsin and octopus metarhodopsin wherein said monoclonal antibody binds with higher affinity to metarhodopsin than to rhodopsin and does not inhibit rhodopsin-metarhodopsin interconversion upon exposure to blue or red light. The monoclonal antibody binds to a peptide having the sequence Val-Ile-Gly-Arg-Pro-Met-Ala-Ala-Ser-Lys-Lys-Met-Ser. The photochemical reaction of rhodopsin thin layers may be detected using the anti-rhodopsin monoclonal antibodies of the invention.
REFERENCES:
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J. Cell. Biol. vol. 105 (5 pt.2), 1985, p. 222a, abstract No. 843; L. J. Robles et al.: "Monoclonal antibody localization of opsin in squid photoreceptors".
Imazeki Shuji
Ishibashi Tadashi
Kezuka Hiroaki
Shimizu Norio
Tsuda Motoyuki
Hitachi , Ltd.
Hutzell Paula K.
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