Anti-obesity drugs

Details Anti-obesity drugs Anti-obesity drugs

1996-03-18

1997-02-11

Jordan, Kimberly

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514419, 514423, 514532, 514538, 514547, 514549, 514550, 514551, 514556, 514617, 514619, 514621, 514626, 514627, 514909, A61K 31415, A61K 3140, A61K 31235, A61K 3124

Patent

active

056021640

ABSTRACT:
Obesity is treated by the administration to a subject of a compound having the general formula (I): R.sub.4 --(CH.sub.2).sub.n --CO--N(R.sub.1)--CH(R.sub.2)--CO(--R.sub.3), wherein R.sub.1 represents H or CH.sub.3 ; R.sub.2 represents a side chain of a naturally occurring amino acid; R.sub.3 represents OH, OCH.sub.2 CH.sub.3 and NH.sub.2 ; n is 6-18; and R.sub.4 represents CH.sub.3 or a group having the general formula (II): R.sub.3 --CO--CH(R.sub.2)--N(R.sub.1)--CO--, wherein R.sub.1, R.sub.2 and R.sub.3 have the above meanings. The compounds of formula (I) wherein R.sub.4 is a group of formula (II), are novel compounds.

REFERENCES:
patent: 4634795 (1987-01-01), Bar-Tana
patent: 4689344 (1987-08-01), Bar-Tana
patent: 4711896 (1987-12-01), Bar-Tana et al.
patent: 4908385 (1990-03-01), Bar-Tana et al.
J. Bar-Tana, et al., Inhibition of Lipid Synthesis by .beta..beta.'-Tetramethyl-Substituted, C.sub.14 -C.sub.22, .varies.,w-Dicarboxylic Acids in the Rat In Vivo*, vol. 260, No. 14, pp. 8404-8410, 1985.
G. Rose-Kahn, et al., Inhibition of Lipid Syntesis by .beta..beta.-Tetramethyl-Substituted, C.sub.14 -C.sub.22, .varies., w-Dicarboxylic Acids in Cultured Rat Hepatocytes*, vol. 260, No. 14, pp. 8411-8415.
J. Bar-Tana, et al., Hypolipidemic Effect of .beta.,.beta.-Methyl-Substituted Hexadecanedioic Acid (MEDICA 16) in Normal and Nephro Rats, vol. 29, pp. 431-441, 1988.
B. Frenkel, et al., The Hypochylomicronemic Effect of .beta.,.beta.-Methyl Substituted Hexadecanedioic Acid (MEDICA 16) Is Mediated by a Decrease in Apolipoprotein C-III*, vol. 263, No. 17, pp. 8491-8497, 1988.
R. Tzur, et al., Hypolipidemic, Antiobesity, and Hypoglycemic-Hypoinsulinemic Effects of .beta.,.beta.'-Methyl-Substituted Hexadecanedioi Acid in Sand Rats, vol. 37, pp. 1618-1624, Dec.-1988.

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