Anti-obese immunogenic hybrid polypeptides and anti-obese...

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence

Reexamination Certificate

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C530S300000, C530S350000, C435S069100

Reexamination Certificate

active

07829667

ABSTRACT:
Disclosed is an immunogenic hybrid polypeptide comprising a mimetic peptide of a B cell epitope of apolipoprotein B-100 and a helper T cell epitope, the mimetic peptide being fused at its C-terminus to an N-terminus of the helper T cell epitope. Also disclosed is a vaccine composition for preventing or treating obesity comprising the polypeptide.

REFERENCES:
patent: 5843446 (1998-12-01), Ladd
patent: 6284533 (2001-09-01), Thomas
patent: 6541011 (2003-04-01), Punnonen et al.
patent: 1392798 (2003-01-01), None
patent: 0406316 (1995-01-01), None
patent: 1020020018971 (2002-03-01), None
patent: WO/02/20040 (2002-03-01), None
patent: WO03015812 (2003-02-01), None
patent: WO2004001997 (2004-03-01), None
Walley AJ, et al. “The genetic contribution to non-syndromic human obesity.” Nat Rev Genet. Jul. 2009;10(7):431-42.
Leclerc, C., et al; Immunodominance of a Recombinant T-Cell Epitope Depends on its Molecular Environment; Molecular Immunology, vol. 30, No. 17, pp. 1561-1572; 1993.
Pfitzner, R., et al; Isolation, Expression and Characteriation of a Human Apoliporotein B 100-Specific cDNA Clone; Biol. Chem.; vol. 367, pp. 1077-1083; Oct. 1986.
Wu, R., et al; Autoantibodies to OxLDL are decreased in individuals with borderline hypertension; Hypertension Journal of the American Heart Association; Online ISSN: 1524-4563.
Partidos, C., et al. The effect of orientation of epitopes on the immunogenicity of chimeric synthetic peptides representing measles virus protein sequences; Molecular Immunology; vol. 29, No. 5, pp. 651-658; 1992.
Francis, M., et al; Non-responsiveness to a foot-and-mouth disease virus peptide overcome by addition of foreigh helper T-cell determinants. Nature, vol. 300; November.
Palinski, W., et al; Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdhyde-modified LDL reduces atherogenesis. Proc. Natl. Acad. Sci. USA, vol. 92, pp. 821-825; Jan. 1995.
Bailey, J.M.; Cholesterol Vaccines; Science, vol. 264; May 1994.

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