Anti-neurogenic inflammatory compounds and compositions and meth

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

514397, 514402, 514497, A61K 3140, A61K 31415, A61K 31495

Patent

active

060908114

ABSTRACT:
A novel use for the class of biologically active bis-heterocyclic, e.g., bis-indole alkaloid compounds, which have been named topsentins, bromotopsentins, homocarbonyltopsentins, nortopsentins, hamacanthins, bis-indole ethylamines, or dragmacidins, pharmaceutical compositions containing the compounds, methods of producing the compounds, and methods of using the compounds are disclosed. Specifically, the novel utility pertains to the anti-neurogenic inflammatory properties exhibited by the bis-indole compounds and their analogs.

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Uemura, D. et al. (1985) "Norhalichondrin A: An Antitumor Polyether Macrolide from a Marine Sponge" J. Am. Chem. Soc. 107:4796-4798.
Moquin, D., M. Guyot (1984) "Grossularine, A Novel Indole Derivative from the Marine Tunicate, Dendrodoa grossularia" Tetrahedron Letters 25(44):5047-5048.

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