Anti-neoplastic 1,4-bis-(substituted aminoalkyl amino)-anthraqui

Details Anti-neoplastic 1,4-bis-(substituted aminoalkyl amino)-anthraqui Anti-neoplastic 1,4-bis-(substituted aminoalkyl amino)-anthraqui

1979-06-19

1982-01-12

Douglas, Winston A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

260378, 260379, 260380, C07D24104, C07C 9712, C07C 9724, C07C 9726

Patent

active

043106668

ABSTRACT:
An antineoplastic 1,4-bis-substituted-9-10-anthracenedione having the formula ##STR1## wherein W, X, Y and Z are each independently selected from the group consisting of hydrogen, OH, NH.sub.2, OCH.sub.3, N(CH.sub.3).sub.2, F, Cl, Br, I, alkyl groups containing from 1-8 carbon atoms, glucosides, phenyl and substituted phenyl, and R is selected from the group consisting of alkyl amino groups containing from 1-8 carbon atoms, alkylaminoalkyl groups containing from 1-8 carbon atoms, substituted alkylamino-alkyl groups containing from 1-8 carbon atoms, and substituted aminoaryl groups.

REFERENCES:
patent: 1014204 (1912-01-01), Berchelmann
patent: 1911316 (1933-05-01), Hauser et al.
patent: 3881865 (1975-05-01), Greenhalgh et al.
patent: 3960751 (1976-06-01), Moriyama et al.
patent: 4051155 (1977-09-01), Hoare
patent: 4138415 (1979-02-01), Murdock et al.
patent: 4197249 (1980-04-01), Murdock et al.
Chemical Abstracts, vol. 80, #16443j, 1972, "1,4 Diamino Anthraquinone Dyes" Schmidt.
Journal of Medicinal Chemistry, vol. 83, pp. 291-294, "Antineoplastic Agents", Zee-Cheng et al., 1978.
Chemical Abstracts, vol. 83, #201736g, 1975 "Interaction of Aminoalkylamino Anthraquinones with Deoxyribonucleic Acid".

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