Anti-MPL antibodies

Details Anti-MPL antibodies Anti-MPL antibodies

2011-08-09

2011-08-09

Shafer, Shulamith H (Department: 1647)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

C530S388100, C530S387300, C530S387900, C530S388150, C530S388220

Reexamination Certificate

active

07993642

ABSTRACT:
Anti-human Mpl antibodies were isolated and purified. Anti-human Mpl diabodies and anti-human Mpl sc(Fv)2 were prepared using genetic engineering techniques and anti-human Mpl sc(Fv)2 was also humanized. The diabodies and sc(Fv)2 were assayed for TPO-like agonistic activity, and were found to have activities higher than those of anti-human Mpl antibodies, or activities equivalent to or higher than those of naturally-occurring human TPO ligand.

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