Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...
Reexamination Certificate
2011-08-30
2011-08-30
Shafer, Shulamith H (Department: 1647)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Animal cell, per se, expressing immunoglobulin, antibody, or...
C435S343000, C435S328000, C435S330000, C435S331000, C435S325000, C435S069100, C435S320100, C536S025500, C536S023100
Reexamination Certificate
active
08008073
ABSTRACT:
Anti-human Mpl antibodies were isolated and purified. Anti-human Mpl diabodies and anti-human Mpl sc(Fv)2 were prepared using genetic engineering techniques and anti-human Mpl sc(Fv)2 was also humanized. The diabodies and sc(Fv)2 were assayed for TPO-like agonistic activity, and were found to have activities higher than those of anti-human Mpl antibodies, or activities equivalent to or higher than those of naturally-occurring human TPO ligand.
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Hirata Yuichi
Nakano Kiyotaka
Orita Tetsuro
Tsuchiya Masayuki
Tsunoda Hiroyuki
Chugai Seiyaku Kabushiki Kaisha
Fish & Richardson P.C.
Shafer Shulamith H
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