Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Oxidoreductases
Patent
1995-07-31
1998-06-09
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Oxidoreductases
424 943, A61K 3844, A61K 3854
Patent
active
057629293
ABSTRACT:
The present invention relates to an novel anti-motoneuron-disease agent, comprising superoxide dismutase conjugated with lecithin through chemical crosslinking represented in the following generic formula (PC-SOD) as an effective ingredient:
wherein SOD represents superoxide dismutase and X represents a residue of lysolecithin having a hydroxy group at position 2 of glycerol whose hydrogen atom of the hydroxyl group at position 2 is removed.
A pharmaceutical agent of the present invention may improve symptoms of motoneuron diseases such as amyotrophic lateral sclerosis etc. by oral or parenteral administration. The present invention also relates to a novel treatment method for motoneuron disease by administrating PC-SOD and novel use of PC-SOD as a medical composition for preparing an agent for treating motoneuron disease.
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Ikeda Ken
Iwasaki Yasuo
Kinoshita Masao
Kobayashi Tomoko
Shiojima Toshiya
Criares Theodore J.
SAM Research Corporation
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