Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Patent
1988-05-27
1989-04-11
Kight, John
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
435 31, 435 32, 435 33, 604368, C08K 541, C08K 534, C08K 515, C08K 510
Patent
active
048202924
ABSTRACT:
An anti-microbial sensitivity test and testing stratum is disclosed for evaluating the sensitivity of different anti-microbial agents relative to identifiable microbial contaminants. The test stratum comprises a polymer such as poly(2-hydroxyethylmethacrylate) referred to as PHEMA, an organic solvent, such as polyethylene glycol (PEG), a hydrogen binding plasticizer, such as dimethylsulfoxide (DMSO), an an anti-microbial agent such as silver sulfadiazine, mafenide, nystatin, nitrofurazone, silver nitrate, bacitracin, gentamicin, amphotericin B, cesium nitrate, or other anti-microbial agents. The test includes positioning testing stratum of the type described, each having a different anti-microbial agent therein, on a sterile plate or on an agar substrate and spaced in fixed relationship to one another. The testing stratum are self adhering and remain fixed on a sterile plate, or on an applicator, even when the sterile plate, is inverted. The testing stratum further provide a sustained release of the anti-microbial agent incorporated therein. The testing stratum are then subjected to samples from the wound site, often containing microbial contaminants, and after a predetermined period of incubation, evaluation indicative of microbial contamination can then be made and examination of the zones of inhibition over and around each of the anti-microbial testing stratum will determine effectiveness of each anti-microbial agent contained in the test system.
REFERENCES:
patent: 3960658 (1976-06-01), Avakian et al.
patent: 4311794 (1982-01-01), Melnick et al.
Korol Bernard
Nathan Paul
Azpuru Carlos
Denk Paul M.
Enguay Pharmaceutical Associates
Kight John
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