Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Biocides; animal or insect repellents or attractants
Patent
1995-06-02
1998-11-17
Levy, Neil S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Biocides; animal or insect repellents or attractants
424411, 424417, 424421, 424617, 424618, A01N 2512
Patent
active
058372750
ABSTRACT:
Anti-microbial coatings and method of forming same on medical devices are provided. The coatings are preferably formed by depositing an anti-microbial, biocompatible metal by vapor deposition techniques to produce atomic disorder in the coating such that a sustained release of metal ions sufficient to produce an anti-microbial effect is achieved. Preferred deposition conditions to achieve atomic disorder include a lower than normal substrate temperature, and one or more of a higher than normal working gas pressure and a lower than normal angle of incidence of coating flux. Anti-microbial powders formed by vapor deposition or altered by mechanical working to produce atomic disorder are also provided. Novel anti-microbial silver materials are defined, characterized by having a positive rest potential, a T.sub.rec /T.sub.m less than 0.33, and a grain size less than 200 nm. Anti-microbial fine grain or nanocrystalline materials are provided, together with methods of preparation, wherein the anti-microbial metal if deposited in a matrix with atoms or molecules of a different material such as other biocompatible metals (ex. Ta), trapped or absorbed oxygen, or compounds of anti-microbial metals or biocompatible metals (ex. AgO or TaO).
REFERENCES:
patent: 2103999 (1937-12-01), Muller et al.
patent: 2785153 (1957-03-01), Locke et al.
patent: 4043932 (1977-08-01), Fresenius et al.
patent: 4054139 (1977-10-01), Crossley
patent: 4167045 (1979-09-01), Sawyer
patent: 4325776 (1982-04-01), Menzel
patent: 4341569 (1982-07-01), Yaron et al.
patent: 4377675 (1983-03-01), Daudt et al.
patent: 4404233 (1983-09-01), Ikeda et al.
patent: 4411041 (1983-10-01), Braga
patent: 4411648 (1983-10-01), Davis et al.
patent: 4418686 (1983-12-01), Child
patent: 4443488 (1984-04-01), Little et al.
patent: 4476590 (1984-10-01), Scales et al.
patent: 4483688 (1984-11-01), Akiyama
patent: 4520039 (1985-05-01), Ovshinsky
patent: 4528208 (1985-07-01), Hirvonen
patent: 4543275 (1985-09-01), Akashi et al.
patent: 4564361 (1986-01-01), Akiyama
patent: 4569673 (1986-02-01), Tesi
patent: 4590031 (1986-05-01), Eichen et al.
patent: 4592920 (1986-06-01), Murtfeldt
patent: 4603152 (1986-07-01), Laurin et al.
patent: 4612337 (1986-09-01), Fox, Jr. et al.
patent: 4615705 (1986-10-01), Scales et al.
patent: 4642104 (1987-02-01), Sakamoto et al.
patent: 4657772 (1987-04-01), Kocak
patent: 4664960 (1987-05-01), Ovshinsky
patent: 4670292 (1987-06-01), Fujita et al.
patent: 4677143 (1987-06-01), Laurin et al.
patent: 4683149 (1987-07-01), Suzuki et al.
patent: 4693760 (1987-09-01), Sioshansi
patent: 4716083 (1987-12-01), Eichen et al.
patent: 4718905 (1988-01-01), Freeman
patent: 4743308 (1988-05-01), Sioshansi et al.
patent: 4743493 (1988-05-01), Sioshansi et al.
patent: 4846834 (1989-07-01), von Recum et al.
patent: 4849223 (1989-07-01), Pratt et al.
patent: 4855026 (1989-08-01), Sioshansi
patent: 4867968 (1989-09-01), Allen
patent: 4886505 (1989-12-01), Haynes et al.
patent: 4902503 (1990-02-01), Umemura et al.
patent: 4906466 (1990-03-01), Edwards et al.
patent: 4923450 (1990-05-01), Maeda et al.
patent: 4932948 (1990-06-01), Kernes et al.
patent: 4933178 (1990-06-01), Capelli
patent: 4944961 (1990-07-01), Lu et al.
patent: 4952419 (1990-08-01), De Leon et al.
patent: 4960415 (1990-10-01), Reinmuller
patent: 4973320 (1990-11-01), Brenner et al.
patent: 5005518 (1991-04-01), Yamada
patent: 5019096 (1991-05-01), Fox, Jr. et al.
patent: 5019601 (1991-05-01), Allen
patent: 5045318 (1991-09-01), Tengvall et al.
patent: 5047385 (1991-09-01), Beasley et al.
patent: 5049140 (1991-09-01), Brenner et al.
patent: 5055169 (1991-10-01), Hock, Jr. et al.
patent: 5057106 (1991-10-01), Kasevich et al.
patent: 5073382 (1991-12-01), Antelman
patent: 5078902 (1992-01-01), Antelman
patent: 5080671 (1992-01-01), Oron et al.
patent: 5089275 (1992-02-01), Antelman
patent: 5098434 (1992-03-01), Serbousek
patent: 5098582 (1992-03-01), Antelman
patent: 5108399 (1992-04-01), Eitenmuller et al.
patent: 5123924 (1992-06-01), Sioshansi et al.
patent: 5123927 (1992-06-01), Duncan et al.
patent: 5133757 (1992-07-01), Sioshansi et al.
patent: 5152774 (1992-10-01), Schroeder
patent: 5152783 (1992-10-01), Suzuki et al.
patent: 5152993 (1992-10-01), Bjursten et al.
patent: 5180585 (1993-01-01), Jacobson et al.
patent: 5207706 (1993-05-01), Menaker
patent: 5211855 (1993-05-01), Antelman
patent: 5223149 (1993-06-01), Antelman
patent: 5242706 (1993-09-01), Cotell et al.
patent: 5248772 (1993-09-01), Siiman et al.
patent: 5322520 (1994-06-01), Milder
patent: 5405644 (1995-04-01), Ohsumi et al.
patent: 5427631 (1995-06-01), Johansson et al.
patent: 5454886 (1995-10-01), Burrell et al.
patent: 5468562 (1995-11-01), Farivar et al.
patent: 5474797 (1995-12-01), Sioshansi et al.
patent: 5520664 (1996-05-01), Bricault, Jr. et al.
Derwent Abstract of Japan 04-2228532, Feb. 19, 1998.
H.E. Morton, "Pseudomonas," in Antiseptics and Disinfectants, 401-411 (S.S. Block. Lea, and Febiger ed. 1977).
N. Grier, "Silver and Its Compounds," in Antiseptics and Disinfectants, 375-389 (S.S. Block, Lea, and Febiger ed. 1977).
E. Deitch et al., "Silver-Nylon: A New Antimicrobial Agent," Antimicrobial Agents and Chemotherapy, vol. 23 (3):356-359 (Mar. 1983).
P. MacKeen et al., "Silver-Coated Nylon Fiber as an Antibacterial Agent." Antimicrobial Agents and Chemotherapy, vol. 31 (1):93-99 (Jan. 1987).
A. Marino et al., "Electrical Augmentation of the Antimicrobial Activity of Silver-Nylon Fabrics," Journal of Biological Physics,vol. 12:93-98 (1984).
M. Tanemura et al., "Growth of microprojections arising from sputter etching of Cu-Ag sandwich," J. Vac. Sci. Technol., vol. 4, (5):2369-2372 (Sep./Oct. 1986).
R. Bunshah, "Deposition Technologies: An Overview," in Deposition Technologies for Films and Coatings, Noyes Publications, NJ, 1-18 (1982).
J. Thornton, "Influence of apparatus geometry and deposition conditions on the structure and topography of thick sputtered coatings," J. Vac. Sci. Technol., vol. 11, (4):666-670 (Jul./Aug. 1974).
R.P. Andres et al., "Research opportunities on clusters and cluster-assembled materials --A Departmant of Energy, Council on Materials Science Panel Report," J. Mater. Res., vol. 4, (3):704-736 (May/Jun. 1989).
J. Nickel et al., "Antibiotic Resistance of Pseudomonas aeruginosa Colonizing a Urinary Catherter in Vivo," Eur, J. Clin. Microbiol., vol. 4 (2):213-218 (Apr. 1985).
Product Brochures;SPI-Argent.
P. Sioshansi, "Surface Coatings by lon Beam Asisted Deposition," presented at Thin Films '91 San Diego, California, Sep. 26 and 27, 1991.
Letter and enclosures dated Dec. 16, 1991, from John E. Barry (Spire Corporation) to Applicant, Dr. Burrell.
Announcement by Spire Corp. in New Coatings and Surfaces, Sep. 1991.
S. Barranco et al., "In Vitro Effect of Weak Direct Current on Staphylococcus Aureus," Clinical Orthopaedics and Related Research, No. 100, 250-255 (May 1974).
J. Spadaro et al., "Antibacterial Effects of Silver Electrodes with Weak Direct Current," Antimicrobial Agents and Chemotherapy, vol. 6 (5):637-642 (Nov. 1974).
J. Spadaro et al., "Some Specific Cellular Effects of Electrically Injected Silver and Gold Ions," Bioelectrochem. and Bioenergetics, No. 3, 49-57 (1976).
T. Berger et al., "Electically Generated Silver Ions: Quantative Effects on Bacterial and Mammalian Cells," Antimicrobial Agents and Chemotherapy, 357-358 (Feb. 1976).
T. Berger et al., "Antifungal Properties of Electrically Generated Metallic Ions," Antimicrobial Agents and Chemotherapy, vol. 10(5):856-860 (Nov. 1976).
J. Spadaro et al., "Antibacterial Effects of Silver Electrode," Eng. in Med. & Biol. Soc., 215-218 (1981).
D. Webster et al., "Silver Anode Treatment of Chronic Osteomyelitis," Clinical Orthopaedics and Related Research, No. 161, 105-114 (Nov./Dec. 1981).
C. Davis et al., "Iontophoretic Killing Escherichia coli in Statis Fluid and in a Model Catherter System," Journal of Clinical Microbiology, vol. 15(5):891-894 (May 1982).
J. Spadaro et al., "Antibacterial Fixation Pins with Silver: Animal Models," J. Biol. Phys., No. 12 (1984).
A. Marino et al., "Electrochemical Pr
Apte Prasad Shrikrishna
Burrell Robert Edward
Gill Kashmir Singh
Morris Larry Roy
Sant Sudhindra Bharat
Levy Neil S.
Westaim Technologies Inc.
LandOfFree
Anti-microbial materials does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anti-microbial materials, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-microbial materials will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-881617