Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Biocides; animal or insect repellents or attractants
Patent
1993-11-18
1999-09-28
Levy, Neil S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Biocides; animal or insect repellents or attractants
424405, 424421, 424618, A01N 2512
Patent
active
059584408
ABSTRACT:
Anti-microbial coatings and method of forming same on medical devices are provided. The coatings are preferably formed by depositing an anti-microbial, biocompatible metal by vapour deposition techniques to produce atomic disorder in the coating such that a sustained release of metal ions sufficient to produce an anti-microbial effect is achieved. Preferred deposition conditions to achieve atomic disorder include a lower than normal substrate temperature, and one or more of a higher than normal working gas pressure and a lower than normal angle of incidence of coating flux. Anti-microbial powders formed by vapour deposition or altered by mechanical working to produce atomic disorder are also provided. Novel anti-microbial silver materials are defined, characterized by having a positive rest potential, a T.sub.rec /T.sub.m less than 0.33, and a grain size less than 200 nm. Anti-microbial fine grain or nanocrystalline materials are provided, together with methods of preparation, wherein the anti-microbial metal if deposited in a matrix with atoms or molecules of a different material such as other biocompatible metals (ex. Ta), trapped or absorbed oxygen, or compounds of anti-microbial metals or biocompatible metals (ex. Ag0 or TaO).
REFERENCES:
patent: 2103999 (1937-12-01), Muller et al.
patent: 2785153 (1957-03-01), Locke et al.
patent: 4043932 (1977-08-01), Fresenius et al.
patent: 4054139 (1977-10-01), Crossley
patent: 4167045 (1979-09-01), Sawyer
patent: 4325776 (1982-04-01), Menzel
patent: 4341569 (1982-07-01), Yaron et al.
patent: 4377675 (1983-03-01), Daudt et al.
patent: 4404233 (1983-09-01), Ikeda et al.
patent: 4411041 (1983-10-01), Braga
patent: 4411648 (1983-10-01), Davis et al.
patent: 4418686 (1983-12-01), Child
patent: 4443488 (1984-04-01), Little et al.
patent: 4476590 (1984-10-01), Scales et al.
patent: 4483688 (1984-11-01), Akiyama
patent: 4520039 (1985-05-01), Ovshinsky
patent: 4528208 (1985-07-01), Hirvonen
patent: 4543275 (1985-09-01), Akashi et al.
patent: 4564361 (1986-01-01), Akiyama
patent: 4569673 (1986-02-01), Tesi
patent: 4590031 (1986-05-01), Eichen et al.
patent: 4592920 (1986-06-01), Murtfeldt
patent: 4603152 (1986-07-01), Laurin et al.
patent: 4612337 (1986-09-01), Fox, Jr. et al.
patent: 4615705 (1986-10-01), Scales et al.
patent: 4642104 (1987-02-01), Sakamoto et al.
patent: 4657772 (1987-04-01), Kocak
patent: 4664960 (1987-05-01), Ovshinsky
patent: 4670292 (1987-06-01), Fujita et al.
patent: 4677143 (1987-06-01), OLaurin et al.
patent: 4683149 (1987-07-01), Suzuki et al.
patent: 4693760 (1987-09-01), Sioshansi
patent: 4716083 (1987-12-01), Eichen et al.
patent: 4718905 (1988-01-01), Freeman
patent: 4743308 (1988-05-01), Sioshansi et al.
patent: 4743493 (1988-05-01), Sioshansi et al.
patent: 4846834 (1989-07-01), von Recum et al.
patent: 4849223 (1989-07-01), Pratt et la.
patent: 4855026 (1989-08-01), Sioshansi
patent: 4867968 (1989-09-01), Allen
patent: 4886505 (1989-12-01), Haynes et al.
patent: 4902503 (1990-02-01), Umemura et al.
patent: 4906466 (1990-03-01), Edwards et al.
patent: 4923450 (1990-05-01), Maeda et al.
patent: 4932948 (1990-06-01), Kernes et al.
patent: 4933178 (1990-06-01), Capelli
patent: 4944961 (1990-07-01), Lu et al.
patent: 4952419 (1990-08-01), De Leon et al.
patent: 4960415 (1990-10-01), Reinmuller
patent: 4973320 (1990-11-01), Brenner et al.
patent: 5005518 (1991-04-01), Yamada
patent: 5019096 (1991-05-01), Fox, Jr. et al.
patent: 5019601 (1991-05-01), Allen
patent: 5045318 (1991-09-01), Tengvall et al.
patent: 5047385 (1991-09-01), Beasley et al.
patent: 5049140 (1991-09-01), Brenner et al.
patent: 5055169 (1991-10-01), Hock, Jr. et al.
patent: 5057106 (1991-10-01), Kasevich et al.
patent: 5073382 (1991-12-01), Antelman
patent: 5078902 (1992-01-01), Antelman
patent: 5080671 (1992-01-01), Oron et al.
patent: 5084096 (1992-01-01), Stovicek
patent: 5089275 (1992-02-01), Antelman
patent: 5098434 (1992-03-01), Serbousek
patent: 5098582 (1992-03-01), Antelman
patent: 5108399 (1992-04-01), Eitenmuller et al.
patent: 5123924 (1992-06-01), Sioshansi et al.
patent: 5123927 (1992-06-01), Duncan et al.
patent: 5133757 (1992-07-01), Sioshansi et al.
patent: 5152774 (1992-10-01), Schroeder
patent: 5152783 (1992-10-01), Suzuki et al.
patent: 5152993 (1992-10-01), Bjursten et al.
patent: 5180585 (1993-01-01), Jacobson et al.
patent: 5207706 (1993-05-01), Menaker
patent: 5211855 (1993-05-01), Antelman
patent: 5223149 (1993-06-01), Antelman
patent: 5242706 (1993-09-01), Cotell et al.
patent: 5248772 (1993-09-01), Siiman et al.
patent: 5320908 (1994-06-01), Sodervall et al.
patent: 5322520 (1994-06-01), Milder
patent: 5405644 (1995-04-01), Ohsumi et al.
patent: 5427631 (1995-06-01), Johansson et al.
patent: 5454886 (1995-10-01), Burrell et al.
patent: 5468562 (1995-11-01), Farivar et al.
patent: 5474797 (1995-12-01), Sioshansi et al.
patent: 5520664 (1996-05-01), Bricault, Jr. et al.
patent: 5709677 (1998-01-01), Slatkine
Liedberg, H., et al., "Assessment of Silver-Coated Urinary Catheter Toxicity by Cell Culture," Urological Research (1989) 17:359-360.
Liedberg, H., et al., "Silver Coating of Urinary Catheters Prevents Adherence and Growth of Pseudomonas Aeruginosa," Urological Research (1989) 17:357-358.
Liedberg, H., et al., "Silver Alloy Coated Catheters Reduce Catheter-Associated Bacteriuria," Br. J. Urol. (1990) Apr., 65(40):379-381.
Derwent Abstract of Japan 04-2228532, Feb. 19, 1998.
PCT Search Report.
Spadaro, J.A., et al, 1979. "Silver Polymethyl Methacrylate Antibacterial Bone Cement" Clinical Orthopaedics and Related Research, No. 143, Sep. 1979, pp. 266-270.
Becker, R.O., et al., 1978. "Treatment of Orthopaedic Infections with Electrically Generated Silver Ions" The Journal of Bone and Joint Surgery, vol. 60-A, No. 7, Oct. 1978, pp. 871-881.
Research & Development Magazine, Oct. 1993, Consumer Products "Sildate".
Gleiter, H., 1992. "Materials With Ultrafine Microstructures: Retrospective and Perspectives" NanoStructured Materials, vol. 1, pp. 1-19.
Birringer, R., et al., 1986. "Nanocrystalline Materials--A First Report" Grain Boudary Structure and Related Phenomena Proceedings of JIMIS-4(1986). Supplement to Transactions of the Japan Institute of Metals.
Colmano, G., et al., 1980. "Activation of Antibacterial Silver Coatings on Surgical Implants by Direct Current: Preliminary Studies in Rabbits", Am.J.Vet.Res., vol. 41, No. 6, 1980, pp. 964-966.
Spadaro, J.A., et al., 1983. "Direct Current Activation of Bacteriostatic Silver Electrodes--1983 abstact--Transactions of the Bioelectric Repair and Growth Society", vol., p. 37.
Spadaro, J.A., et al., 1981. "Electrical Activation of Silver Bacteriostasis--Transactions of Society for Biomaterials", vol. 4, p. 70, 1981--presented at the 7th Annual Meeting Society for Biomaterials, Troy New York, May 29, 1981.
R. Bunshah, "Deposition Technologies: An Overview," in Deposition Technologies for Films and Coatings, Noyes Publications, NJ, 1-18 (1982).
J. Thornton, "Influence of apparatus geometry and deposition conditions on the structure and topography of thick sputtered coatings," J. Vac. Sci. Technol., vol. 11, (4):666-670 (Jul./Aug. 1974).
R.P. Andres et al., "Research opportunities on clusters and cluster-assembled materials--A Department of Energy, Council on Materials Science Panel Report," J. Mater. Res., vol. 4, (3):704-736 (May/Jun. 1989).
J. Nickel et al., "Antibiotic Resistance of Pseudomonas aeruginosa Colonizing a Urinary Catheter in Vivo," Eur. J. Clin. Microbiol., vol. 4 (2):213-218 (Apr. 1985).
Product Brochures; SPI-ARGENT.
P. Sioshansi, "Surface Coatings by Ion Beam Assisted Deposition," presented at Thin Films '91, San Diego, California, Sep. 26 and 27, 1991.
Letter and enclosures dated Dec. 16, 1991, from John E. Bary (Spire Corporation) to Applicant, Dr. Burrell.
Announcement by Spire Corp. in New Coatings and Surfaces, Sep. 1991.
S. Barranco et al., "In Vitro Effect of Weak Direct Current on Staphylococcus Aureus," Clinical Orthopaedics and Related Research, No. 100, 250-255 (May 1974).
J. Spadaro et al., "Antibacterial Effects of Silver Electrodes with Weak Direc
Apte Prasad Shrikrishna
Burrell Robert Edward
Gill Kashmir Singh
Morris Larry Roy
Sant Sudhindra Bharat
Levy Neil S.
Westaim Technologies Inc.
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