Anti-microbial compositions

Details Anti-microbial compositions Anti-microbial compositions

1995-12-11

1997-09-30

Venkat, Jyothsan

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

424 49, 424405, 514 2, A61K 600, A61K 748

Patent

active

056723512

ABSTRACT:
The present invention relates to anti-microbial cosmetic compositions for the care of the human body or parts thereof, comprising derivatives of histatins or fragments thereof. It has been found that the anti-microbial activity of histatins or their fragments can be significantly enhanced by capping them at the C-terminus or at the C- and N-terminus and/or complexing them with anti-microbially-active metal ions. The thus modified histatins and histatin fragments were found to have a significantly increased activity against a range of microbial strains, and were found to be useful as controlled delivery agents for the metal ions. They are suitable for a whole range of anti-microbial applications, such as anti-plaque, and-caries, anti-bad breath oral applications, deodorant applications, personal hygiene applications and so on, for which they are included in any suitable carrier medium. Preferred are the capped derivatives, which have been complexed with Ag, Cu, Zn or Sn.

REFERENCES:
The Journal of Biological Chemistry, vol. 265, No. 7, Mar. 5, 1990, pp. 3898-3905.
Peptides, 1990, pp. 843-846.

Affiliated with

Also associated with

Rating

Anti-microbial compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-microbial compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-microbial compositions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2255037