Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-02-10
1998-10-06
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 8, 530322, 530395, A61K 3800, A61K 3814, C07K 1700
Patent
active
058176187
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/SE93/00684 filed Aug. 17, 1993.
TECHNICAL FILED
The present invention relates to anti-microbial treatment of microbially contaminated materials, bodies and surfaces in general, and in particular to anti-microbial treatment of microbially contaminated water and other liquids, gases and gas mixtures. The invention is also concerned with microbial testing of such materials, bodies and surfaces. As used herein the term "anti-microbial treatment" means that the treatment results in neutralization or inactivation of at least part of the contaminating microbes and preferably of all of the contaminating microbes. As used herein the term "microbes" includes toxins. For simplicity reasons the term "cleaning" is in this specification sometimes used instead of anti-microbial treatment.
BACKGROUND OF THE INVENTION
Microbial contamination is a great problem in many situations. One of the greatest global problems is the cleaning of water, both in developed and developing countries. Water, especially drinking-water, is a scarce resource which has to be re-used. Before using or re-using water as drinking-water it is highly desirable to make sure that the water is clean enough so that it does not constitute a health hazard for the humans or animals who have to drink it.
In the developed countries the problem with contaminated water, especially microbially contaminated water, is most pronounced in urban areas where the drinking-water often is circulated in very large distribution systems. It is usually required that the drinking-water should meet certain standards (prescribed by state, local or other jurisdiction) as regards e.g. physical, chemical and biological properties. Consequently, many procedures have been developed for mechanical, chemical and biological cleaning of water in order to meet these standards. Such cleaning is usually carried out at one or only a few central cleaning stations in the distribution network, and it quite often happens that the cleaned drinking-water becomes re-contaminated during the transport in the distribution system from the cleaning station to the end user. Another frequent problem is that one of the most efficient cleaning treatments, viz. the use UV-radiation, requires absolutely particle-free water in order to be effective. The presently available procedures for eliminating particles (such as sedimentation, flotation, sieving and the like) are, however, incapable of eliminating small microbial particles, so UV-radiation may not inactivate such particles even at the cleaning/disinfecting station.
In many developing countries, and also in parts of developed countries, there are many areas where no water cleaning facilities (central or local) are available, or are only very rudimentary. Since water is a basic need for humans and animals, water is drunk despite the fact that it is known that the water may be contaminated with poisonous or perhaps even lethal microbes. In such situations it would be highly desirable to have an easy-to-use means available for cleaning the water before drinking it, and in many situations already an easy-to-use test for determining whether or not the water is drinkable could be of great help.
There is also a continuing need for efficient anti-microbial agents in many other areas, e.g. for anti-microbial cleaning of surface-contaminated materials such as decontamination of process systems, instruments and equipment, filters for microbially contaminated air and other gases, etc.
A polypeptide fraction has been isolated from a bivalve, Tridacna maxima, by B. A. Baldo et al; Biochem. J. (1978), 175, p. 467-477 "Purification and Characterization of a Galactan-Reactive Agglutinin from The Clam Tridacna maxima (Roding and a Study of its Combining Site)". This isolated fraction is said to have interesting immunological properties. No other use is disclosed or suggested.
EP-A-50 636 discloses a specific polypeptide fraction which has been isolated from the body liquids of Mytilus mussels and the use thereof as an anti-microbial
REFERENCES:
patent: 4801453 (1989-01-01), Kosuge et al.
Baldo et al., Biochem. J., 175, 1978, 467-477.
Hawley's "The Condensed Chemical Dictionary" 10th Ed. (1981, Van Nostrand Reinhold Co.) p. 751.
Celsa Bennett
Micro Active Protein AB
Tsang Cecilia J.
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