Anti-microbial coating for medical device

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

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4272481, 427250, 106 105, 106 113, 106 114, 106 115, 106 116, 106 117, 106 118, 106 119, 106 121, 106723, 106733, A61F 202, C23C 1606, B05B 310

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057532516

ABSTRACT:
Anti-microbial coatings and method of forming same on medical devices are provided. The coatings are formed by depositing a biocompatible metal by vapor deposition techniques to produce atomic disorder in the coating such that a sustained release of metal ions sufficient to produce an anti-microbial effect is achieved. Preferred deposition conditions to achieve atomic disorder include a lower than normal substrate temperature, and one or more of a higher than normal working gas pressure and a lower than normal angle of incidence of coating flux. Anti-microbial powders formed by mechanical working to produce atomic disorder are also provided. The invention extends to other metal coatings and powders similarly formed so as to provide enhanced solubility.

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