Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1995-06-02
1998-05-19
Azpuru, Carlos
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
4272481, 427250, 106 105, 106 113, 106 114, 106 115, 106 116, 106 117, 106 118, 106 119, 106 121, 106723, 106733, A61F 202, C23C 1606, B05B 310
Patent
active
057532516
ABSTRACT:
Anti-microbial coatings and method of forming same on medical devices are provided. The coatings are formed by depositing a biocompatible metal by vapor deposition techniques to produce atomic disorder in the coating such that a sustained release of metal ions sufficient to produce an anti-microbial effect is achieved. Preferred deposition conditions to achieve atomic disorder include a lower than normal substrate temperature, and one or more of a higher than normal working gas pressure and a lower than normal angle of incidence of coating flux. Anti-microbial powders formed by mechanical working to produce atomic disorder are also provided. The invention extends to other metal coatings and powders similarly formed so as to provide enhanced solubility.
REFERENCES:
patent: 2103999 (1937-12-01), Muller et al.
patent: 2785153 (1957-03-01), Locke et al.
patent: 4043932 (1977-08-01), Fresenius et al.
patent: 4054139 (1977-10-01), Crossley
patent: 4167045 (1979-09-01), Sawyer
patent: 4325776 (1982-04-01), Menzel
patent: 4341569 (1982-07-01), Yaron et al.
patent: 4377675 (1983-03-01), Daudt et al.
patent: 4404233 (1983-09-01), Ikeda et al.
patent: 4411041 (1983-10-01), Braga
patent: 4411648 (1983-10-01), Davis et al.
patent: 4418686 (1983-12-01), Child
patent: 4443488 (1984-04-01), Little et al.
patent: 4476590 (1984-10-01), Scales et al.
patent: 4483688 (1984-11-01), Akiyama
patent: 4520039 (1985-05-01), Ovshinsky
patent: 4528208 (1985-07-01), Hirvonen et al.
patent: 4543275 (1985-09-01), Akashi et al.
patent: 4564361 (1986-01-01), Akiyama
patent: 4569673 (1986-02-01), Tesi
patent: 4590031 (1986-05-01), Eichen et al.
patent: 4592920 (1986-06-01), Murtfeldt
patent: 4603152 (1986-07-01), Laurin et al.
patent: 4612337 (1986-09-01), Fox, Jr. et al.
patent: 4615705 (1986-10-01), Scales et al.
patent: 4642104 (1987-02-01), Sakamoto et al.
patent: 4657772 (1987-04-01), Kocak
patent: 4664960 (1987-05-01), Ovshinsky
patent: 4670292 (1987-06-01), Fujita et al.
patent: 4677143 (1987-06-01), Laurin et al.
patent: 4683149 (1987-07-01), Suzuki et al.
patent: 4693760 (1987-09-01), Sioshansi
patent: 4716083 (1987-12-01), Eichen et al.
patent: 4718905 (1988-01-01), Freeman
patent: 4743308 (1988-05-01), Sioshansi et al.
patent: 4743493 (1988-05-01), Sioshansi et al.
patent: 4846834 (1989-07-01), von Recum et al.
patent: 4849223 (1989-07-01), Pratt et al.
patent: 4855026 (1989-08-01), Sioshansi
patent: 4867968 (1989-09-01), Allen
patent: 4886505 (1989-12-01), Haynes et al.
patent: 4902503 (1990-02-01), Umemura et al.
patent: 4906466 (1990-03-01), Edwards et al.
patent: 4923450 (1990-05-01), Maeda et al.
patent: 4932948 (1990-06-01), Kernes et al.
patent: 4933178 (1990-06-01), Capelli
patent: 4944961 (1990-07-01), Lu et al.
patent: 4952419 (1990-08-01), De Leon et al.
patent: 4960415 (1990-10-01), Reinmuller
patent: 4973320 (1990-11-01), Brenner et al.
patent: 5005518 (1991-04-01), Yamada
patent: 5019096 (1991-05-01), Fox, Jr. et al.
patent: 5019601 (1991-05-01), Allen et al.
patent: 5045318 (1991-09-01), Tengvall et al.
patent: 5047385 (1991-09-01), Beasley et al.
patent: 5049140 (1991-09-01), Brenner et al.
patent: 5055169 (1991-10-01), Hock, Jr. et al.
patent: 5057106 (1991-10-01), Kasevich et al.
patent: 5073382 (1991-12-01), Antelman
patent: 5078902 (1992-01-01), Antelman
patent: 5080671 (1992-01-01), Oron et al.
patent: 5089275 (1992-02-01), Antelman
patent: 5098434 (1992-03-01), Serbousek
patent: 5098582 (1992-03-01), Antelman
patent: 5108399 (1992-04-01), Eitenmuller et al.
patent: 5123924 (1992-06-01), Sioshansi et al.
patent: 5123927 (1992-06-01), Duncan et al.
patent: 5133757 (1992-07-01), Sioshansi et al.
patent: 5152774 (1992-10-01), Schroeder
patent: 5152783 (1992-10-01), Suzuki et al.
patent: 5152993 (1992-10-01), Bjursten et al.
patent: 5180585 (1993-01-01), Jacobson et al.
patent: 5207706 (1993-05-01), Menaker
patent: 5211855 (1993-05-01), Antelman
patent: 5223149 (1993-06-01), Antelman
patent: 5233149 (1993-08-01), Antelman
patent: 5242706 (1993-09-01), Cotell et al.
patent: 5322520 (1994-06-01), Milder
patent: 5405644 (1995-04-01), Ohsumi et al.
patent: 5427631 (1995-06-01), Johansson et al.
patent: 5454886 (1995-10-01), Burrell et al.
patent: 5468562 (1995-11-01), Farivar et al.
patent: 5474797 (1995-12-01), Sioshansi et al.
patent: 5520664 (1996-05-01), Bricault, Jr. et al.
Andres, R. P. et al., Materials Reports, "Research opportunities on clusters and cluster-assembled materials--A Department of Energy, Council on Materials Science Panel Report," J. Mater. Res., Vol. 4, No. 3, May/Jun. 1989, pp. 704-734.
Baranco, S.D., M.D. et al., "In Vitro Effect of Weak Direct Current on Staphylococcus Aureus,"Microbiology, Number 100, May, 1974, pp. 250-255.
Becker, Robert 0. et al., "Treatment of Orthopaedic Infections with Electrically Generated Silver Ions," The Journal of Bone and Joint Surgery, American vol. 60-A, No. 7, Oct. 1978, pp. 871-881.
Berger, T.J. et al., "Antifungal Properties of Electrically Generated Metallic Ions," Antimicrobial Agents and Chemotherapy, vol. No., Nov. 1976, pp. 856-860.
Berger, T.J. et al., "Electrically Generated Silver Ions: Quantitative Effects on Bacterial and Mammalian Cells," Antimicrobial Agents and Chemotherapy, Feb. 1976, pp. 357-358.
Birringer, Rainer et al., Nanocrystalline Materials--A First Report, Grain Boundary Structure and Related Phenomena Proceedings of JIMIS-4 (1986). Supplement to Transactions of the Japan Institute of Metals, pp. 43-52.
Bunshah, Rointan F., "Deposition Technologies: An Overview," Materials Science and Engineering Department, University of California, Los Angeles, California, Undated, pp. 1-18.
Burrell, Robert, Dr., Letter dated Dec. 16, 1991, "Infection Resistant Coating," Spi-Argent.TM., Spire Corporation, One Patriots Park, Bedford, Massachusetts, Undated.
Colmano, G., DVM, PhD, et al. Activation of Antibacterial Silver Coatings on Surgical Implants by Direct Current: Preliminary Studies in Rabbits, Microbiology, Undated, pp. 964-966.
Davis, C.P., et al., "lontophoretic Killing of Escherichia coli in Static Fluid and in a Model Catheter System," Journal of Clinical Microbiology, May 1982, pp. 891-894, vol. 15, No. 5.
Davis, C. P., et al., "Effects of Microamperage, Medium, and Bacterial Concentration on lontophoretic Killing of Bacteria in Fluid," Antimicrobial Agents and Chemotherapy, Apr. 1989, pp. 442-447.
Deitch, Edwin A., et al., "Silver-Nylon: A New Antimicrobial Agent," Antimicrobial Agents and Chemotherapy, Mar. 1983, pp. 356-359.
Deitch, Edwin A., et al., "Silver Nylon Cloth: In vitro and in vivo Evaluation of Antimicrobial Activity," The Journal of Trauma, vol. 27, No. 3, 1987, pp. 301-304.
Falcone, Alfred E., D.D.S., M.D., et al. "Inhibitory Effects of Electrically Activated Silver Material on Cutaneous Wound Bacteria," Plastic and Reconstructive Surgery, Mar. 1986, pp. 455-459.
Fores, F. H., et al., "Nanocrystalline Metals for Structural Applications," JOM 41 (1989) Jun., No. 6, Warrendale, Pennsylvania, pp. 12-17.
Gleiter, H., "Materials with Ultrafine Microstructures: Retrospectives and Perspectives," Nanostructured Materials, vol. 1, 1992, pp. 1-19.
Grier, N., Ph.D., "Silver and Its Compounds," Antiseptics and Disinfectants, Undated, pp. 375-389.
Hall, Richard E., D.D.S., M.S., Ph.D., et al. "Inhibitory and Cidal Antimicrobial Actions of Electrically Generated Silver Ions," J. Oral Maxillofac Surg., 45, 1987, pp. 779-784.
Kirchheim, R., et al., "Free Energy of Active Atoms in Grain Boundaries of Nanocrystalline Copper, Nickel and Palladium," Nanostructured Materials, vol. 1, 1992, pp. 167-172.
Lardon, M., et al., "Influence of the substrate temperature and the discharge voltqage on the structure of titanium films produced by ion-plating," Vacuum, vol. 30, No. 7, Pergamon Press Ltd., printed in Great Britain, pp. 255-260.
Morton, H. E., Sc. D., "Pseudomonas," Antiseptics and Disinfectants, (Undated), pp. 401-411.
Nickel, J. C., et al., "Antibiotic Resistance of Pseudomonas aeruginosa Colonizing a Urinary Catheter in Vitro," Eur. J. Clin. Microbiol., Apr. 1985, vol. 4, No. 2., pp. 213-218.
Schlump, Wolf
Burrell Robert Edward
Morris Larry Roy
Azpuru Carlos
Westaim Technologies Inc.
LandOfFree
Anti-microbial coating for medical device does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anti-microbial coating for medical device, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-microbial coating for medical device will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1850503