Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Reexamination Certificate
2005-01-18
2005-01-18
Celsa, Bennett (Department: 1639)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
C424S405000, C424S408000, C424S410000, C424S417000, C424S440000, C424S732000, C424S780000
Reexamination Certificate
active
06843993
ABSTRACT:
A non-food anti-microbial-adhesion and aggregation composition comprising a suitable carrier and an effective amount of an adhesion inhibitory fraction isolated from juice from berries of theVacciniumplant genus. In an embodiment the anti-aggregation and adhesion fraction is isolated from cranberry juice. It is characterized as being polymeric and having a molecular weight ≧14,000; an elemental analysis of carbon 43-51%, hydrogen 4-5%, no nitrogen, no sulfur and no chlorine; a nuclear magnetic resonance (NMR) line spectrum as set forth in FIGS.2A and2B; and an ultraviolet spectrum with an absorption peak at 280 nm in neutral or acidic pH solution which is absent in alkali solutions. This fraction exhibits adhesion inhibitory activity against P fimbriated bacteria, oral bacteria andHelicobacter pylori.
REFERENCES:
patent: 5525341 (1996-06-01), Walker et al.
patent: 5840322 (1998-11-01), Weiss et al.
patent: 6303125 (2001-10-01), Ofek et al.
Ofek et al., Toward Anti-Adhesioin Therapy . . . Diseases, (Plenum Press, NY 1996)_pp. 179-83.
Goldhar Janina
Kashman Yoel
Ofek Itzhak
Sharon Nathan
Weiss Ervin
Celsa Bennett
Kohn & Associates PLLC
Ramot at Tel-Aviv University Ltd.
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