Anti-malarial compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C546S159000

Reexamination Certificate

active

07132431

ABSTRACT:
The present invention relates to pharmaceutical compounds for use in the treatment or porphylaxis of malaria having the general formula: where: R is selected from the group consisting of dimethylamino, diethylamino, di-N-propylamino, diisopropylamino, di-N-butylamino, di-sec-butylamino, piperidinyl, piperizinyl, ethylamino, tert-butylamino; and X is selected from the group consisting of chloro, fluoro, iodo, bromo, trifluoromethyl, methoxy and methyl.

REFERENCES:
patent: 974348 (1961-01-01), None
patent: WO 86/06718 (1986-11-01), None
patent: WO 00/50404 (2000-08-01), None
Werbel et al. (1986) “Synthesis, Antimalarial Activity, and Quantitative Structure-Activity Relationships of Tebuquine and a Series of Related 5-[(7-Chloro-4-quinolinyl)amino]-3-[(alkylamino)methyl][1,1′-biphenyl]-2-ols and N -Oxides” J. Med. Chem. vol. 29: 924-939.
Chemical Abstracts 120:217227, see compounds having Registry Nos. 154179-32-5 and 154179-31-4.
Chemical Abstracts 62:5557g, see compound having Registry No. 1643-45-4.
Aminoalkylphenols as Antimalarials. II. (Heterocyclic-amino)-α-amino-o-cresols. The Synthesis of Camoquin (Apr., 1948). Database Crossfire Beilstein “Online” —Beilstein Institut zur Forderung der Chemischen Wissenschaften, Frankfurt am Main, DE; Database Accession No. 300964—XP002203839.

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