Anti-malarial composition and method of use

Details Anti-malarial composition and method of use Anti-malarial composition and method of use

1992-03-16

2000-12-12

Wilson, James O.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 50, 514261, 514269, 514885, 536 231, A61K 31715

Patent

active

061599530

ABSTRACT:
Anti-malarial compositions for prophylactic or therapeutic treatment of vertebrates exposed to malaria parasites are disclosed. These compositions comprise one or more pyrimidine analogue inhibitors of nucleic acid biosynthesis, e.g., 5-fluoro-orotic acid, alone or together with one or more "rescue" compounds, e.g., a normal pyrimidine base or nucleoside that can be used by the host vertebrate, but not by malaria-causing parasites, for nucleic acid biosynthesis. Also claimed are methods of prophylactic and therapeutic use of these compositions.

REFERENCES:
patent: 3775397 (1973-11-01), Etzold et al.
patent: 4873228 (1989-10-01), Schmalzl et al.
Klubes, P., et al., Cancer Res. 43:3182 (1983).
Hammond, D.J., Molec. Biochem. Pharmacol. 14:97 (1985).
Rathod, P.K., et al., J. Cellular Biochem., Suppl. 13E, Abs. 0555 (1989).
McCormick, G.J., et al., Antimicrob. Agents and Chemotherap., 6:16 (1974).
Ullman, B., et al., Molec. Pharm., 15:357 (1979).
Martin, D.S., et al., Cancer Res. 42:3964 (1982).
Jerry L. Adams, et al., "CIS-4-Carboxy-6-(Mercaptomethyl)-3,4,5,6-Tetrahydropyrimidin-2(1H)-One, A Potent Inhibitor of Mammalian Dihydroorotase" J. Med. Chem. (1988) pp. 1355-1359.

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