Anti-LPS factor from horseshoe crabs and methods of use

Details Anti-LPS factor from horseshoe crabs and methods of use Anti-LPS factor from horseshoe crabs and methods of use

1995-12-22

1998-07-14

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530350, 530857, 424 701, A61K 3800

Patent

active

057804290

ABSTRACT:
This invention is directed to pharmaceutical and cosmetic compositions comprising anti-lipopolysaccharide (anti-LPS) factor proteins derived from horseshoe crabs, either in the native form or produced by recombinant means. The pharmaceutical formulations, which may include anti-LPS factor proteins alone or in combination with other antimicrobials, may be used in the treatment of gram-negative bacterial infections, endotoxemia, septic shock, gram-positive bacterial infections, and yeast infections. The anti-LPS factor protein-containing pharmaceuticals can be formulated for systemic or topical administration. They may also be used to control mold growth. Anti-LPS factor proteins can be used in cosmetic compositions or skin or hair preparations as antimicrobial preservatives, either alone or in combination with conventional preservatives, to prevent or control the growth of bacteria, yeast and mold.

REFERENCES:
patent: 5378731 (1995-01-01), Andrews et al.
patent: 5510120 (1996-04-01), Jones et al.
patent: 5594113 (1997-01-01), Wainwright
Kloczewiak et al. (1994) J. Infect. Dis. 170:1490-1497.
Kuppermann et al. (1994) J. Infect. Dis. 170:630-635.
Warren et al. (1992) Infect. Immun. 60:2506-2513.
Wainwright, et al. In: Cellular and Molecular Aspects of Endotoxin Reactions, Nowotny A., Spitzer, J.J. and Ziegler, E.J., eds., Amsterdam: Elsevier Science 315-324 (1990).
Desch et al. (1989) Infect. Immun. 57:1612-1614.
Morita et al. (1985) J. Biochem. 97:1611-1620.
Alpert et al. (1992) J. Infect. Dis. 165:494-500.
Garcia et al. (1994) Crit. Care Med. 22:8 1211-1218.
Saladino et al. (1994) Circ. Shock 42:104-110.
Kupperman et al. (1992) Pediatr. Res. 3:32A.
Baldwin et al. (1991) J. Infect Dis. 164:542-549.

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