Anti-lipocortin-I and anti-lipocortin-II monoclonal antibodies

Details Anti-lipocortin-I and anti-lipocortin-II monoclonal antibodies Anti-lipocortin-I and anti-lipocortin-II monoclonal antibodies

1989-12-20

1991-09-24

Kepplinger, Esther L.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

530387, 530389, 424 858, 424 8591, 435 7021, C07K 1528, C12N 512, A61K 3900

Patent

active

050513648

ABSTRACT:
The present invention provides monoclonal antibodies which are specific for one but not both of human lipocortin-I and human lipocortin-II, as well as cultures of hybridomas and other types of cells producing such antibodies.

REFERENCES:
Glenney, J. "Two Related but Distinct Forms of the Mr 36,000 Tyrosine Kinase Substrate (Calpactin) that Interact with Phospholipid and Actin in a Ca.sup.2t -Dependent Manner," Proc. Nat'l. Acad. Sci. 83:4258-4262, Jun. 1986.
Courtneidge, S. et al., "Subcellular Location of an Abundant Substrate (p. 36) for Tyrosine-Specific Protein Kinases," Mol. Cell. Biol. 3(3):340-350, Mar. 1983.
Goding, J. W., Monoclonal Antibodies:Principles and Practice, Academic Press, Inc., Orlando, 1983, pp. 68-70.
Morrison, S. L. "Transfectomas Provide Novel Chimeric Antibodies," Science 229:1202-1207, Sep. 20, 1985.
Sawyer, S. T. et al., "Epidermal Growth Factor Stimulates the Phosphorylation of the Calcium-Dependent 35,000-Dalton Substrate in Intact A-431 Cells," J. Biol. Chem. 260(14):8233-8236, Jul. 15, 1985.
Fava, R. et al., "Isolation of a Calcium-Dependent 35-Kilodalton Substrate for the Epidermal Growth Factor Receptor/Kinase from A-431 Cells," J. Biol. Chem. 259(4):2636-2645, Feb. 25, 1984.

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