Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Anti-idiotypic
Reexamination Certificate
2005-03-25
2008-07-15
Blanchard, David J. (Department: 1643)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Anti-idiotypic
C424S130100, C424S133100, C424S138100, C530S387100, C530S387200, C530S387300, C530S387700
Reexamination Certificate
active
07399469
ABSTRACT:
Particular anti-LFL2 antibody compositions are provided herein. These antibodies may be used for diagnosis, prognosis, therapeutic monitoring and treatment of cancer, especially breast cancer, head
eck cancer, lung cancer, ovarian cancer, stomach cancer and pancreatic cancer. Furthermore, anti-LFL2 antibodies are provided herein which target the LFL2 stump remaining after proteolytic cleavage of the extracellular domain of LFL2. Additionally, anti-LFL2 antibodies are provided herein which target the stroma surrounding cancer tumors, wherein said stroma-targeting anti-LFL2 antibodies disrupt the integrity of the stroma surrounding the cancer tumor, and also make the stroma more permeable to chemotherapeutic agents and other molecular drug agents that target tumor cells.
REFERENCES:
patent: 2005/0106644 (2005-05-01), Cairns et al.
patent: 2005/0239700 (2005-10-01), Kloetzer et al.
patent: WO-01/81363 (2001-11-01), None
patent: WO 02/081518 (2002-10-01), None
patent: WO 03/024392 (2003-03-01), None
Lederman et al. Molecular Immunology 28:1171-1181, 1991.
Li et al. Proc. Natl. Acad. Sci. USA 77:3211-3214, 1980.
Byers, T. CA Journal, vol. 49, No. 6, Nov./Dec. 1999.
Gura. Science, v278, 1997, pp. 1041-1042.
Bellone et al. Immunology Today, v20 (10), 1999, pp. 457-462.
Satoh et al., “A Novel Member of the Leucine-Rich Repeat Superfamily Induced in Rat Astrocytes by β-amyloid”, Biochemical and Biophysical Research Communications, vol. 290, pp. 756-762 (2002).
Reynolds et al., “Identification of a DNA-binding site and transcriptional target for EWS-WT1(+KTS) oncoprotein”, Genes & Development, vol. 17, pp. 2094-2107 (2003).
Law Debbie
Ramakrishnan Vanitha
Zhang Yongke
Blanchard David J.
PDL BioPharma, Inc.
Tungaturthi Parithosh K.
LandOfFree
Anti-LFL2 antibodies for the diagnosis, prognosis and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anti-LFL2 antibodies for the diagnosis, prognosis and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-LFL2 antibodies for the diagnosis, prognosis and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3972035