Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only
Patent
1984-11-05
1986-06-10
Moyer, Donald B.
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Polymer from ethylenic monomers only
424 19, 424131, 514943, 514937, A61K 952, A61K 966
Patent
active
045942412
ABSTRACT:
Antimony-containing anti-leishmaniasis drugs are encapsulated in a lipid based liposomal formulation having a weight ratio of lipid to encapsulated antimony-containing drug of 1:1.6 to 1:0.25 and a salt concentration in the continuous aqueous phase which is at least isotonic with human blood. Such formulations are found to have a leakage rate of initially encapsulated antimony-containing drug of less than 50% by weight after storage at 25.degree. C. for 6 weeks from encapsulation and hence provide storage stable formulations which can be used effectively after prolonged storage without refrigeration in tropical climates. The anti-parasital activity of the liposomal formulations has been found greater than that of corresponding aqueous formulations. The liposomal formulations are preferably prepared by a reverse phase evaporation method involving first emulsifying an aqueous solution of the drug with an organic solvent solution of the lipid and then removing the organic solvent at reduced pressure at a temperature below the normal boiling point of the solvent but above the phase transition temperature of the lipid.
REFERENCES:
patent: 3960757 (1979-06-01), Morishita et al.
patent: 4186183 (1980-01-01), Steck et al.
patent: 4235871 (1980-11-01), Papahadjopoulos
Brown Donald
Burroughs Wellcome Co.
Faraci C. Joseph
Moyer Donald B.
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