Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reissue Patent
2002-05-14
2008-10-07
Huff, Sheela J. (Department: 1643)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S388800, C530S387100, C530S387300, C424S009100, C424S133100, C424S130100, C424S156100, C436S518000, C435S007950, C435S328000
Reissue Patent
active
RE040535
ABSTRACT:
An anti-KC-4 humanized monoclonal antibody that comprises the variable regions of the light and heavy chains of the anti-KC-4 murine antibody, wherein the light chain has 7 amino acids and the heavy chain has 12 amino acids of the framework regions substituted with amino acid present in equivalent positions in antibodies of a species other than munne, and the constant regions of a human antibody. The antibody may be labeled and/or glycosylated, and is presented as a composition with a carrier. The anti-KC-4 monoclonal antibody is used in diagnostic kits for cancer and in in vivo methods of imaging and treating a primary or metastasized cancer, and in vitro diagnosis and ex vivo purging neoplastic cells from a biological fluid. RNAs and DNAs encode the monoclonal antibody, and a hybrid vector carrying the nucleotides and transfected cells express the peptides.
REFERENCES:
patent: 4708930 (1987-11-01), Kortright
patent: 5075219 (1991-12-01), Ceriani et al.
patent: 5077220 (1991-12-01), Ceriani et al.
patent: 2 188 638 (1988-10-01), None
Cruse et al., Illustrated Dictionary of Immunology, CRC Press, p. 144, 1994.
Freshney (Culture of Animal Cells, A Manual of Basic Technique, Alan R. Liss, Inc., 1983, New York, p. 4
Dermer (Bio/Technology, 1994, 12:320.
Seaver (1994; Genetic Engineering vol. 14(14): pp. 10 and 21.
Gura (Science, 1997, 278:1041-1042.
Jain (Sci. Am., 1994, 271:58-65.
Trickett (Medical Laboratory sciences 47:120-131, 1990.
Treleaven et al (Hematological Oncology 3:36-75, 1985.
Morrison et al.,Proc. Natl. Acad. Sci, 81:6851-6855, Nov. 1984.
E.A. Padlan,Molecular Immunology, 28:4/5:489-498, 1991.
J.A. Peterson et al.,Biochemical and Histological Characterization of Antigens Preferentially Expressed on the Surface and Cytoplasm of Breast Carcinoma Cells Identified by Monoclonal Antibodies Against the Human Milk Fat Globule, Hybridoma9:221-235, 1990.
D. R. Davies and E. A. Padlan,Antibody-Antigen Complexis, Annu. Rev. Biochem, 59:439-73, 1990.
L. Reichmann et al.,Reshaping Human Antibodies for Therapy, Nature, 332:323-327, 1988.
Dienhart, D.G., et al., “Imaging of non-small cell lung cancers with a monoclonal antibody, KC-4G3, which recognizes a human milk fat globule antigen,” Cancer Res. 50(21):7068-76 (Nov. 1, 1990) (plus Abstract).
Longley, C., et al., “Pharmacokinetics, biodistribution, and gamma camera imaging of111In-KC-4G3 murine monoclonal antibody in athymic nude mice with or without human tumor xenografts,”Cancer Res.50(18):5954-61 (Sep. 15, 1990).
Ceriani Roberto L.
Couto Fernando J. R. do
Peterson Jerry A.
Foley & Lardner LLP
Huff Sheela J.
IBC Pharmaceuticals, Inc.
LandOfFree
Anti-KC4 humanized monoclonal antibody and cells that... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anti-KC4 humanized monoclonal antibody and cells that..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-KC4 humanized monoclonal antibody and cells that... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3987976