Anti-inflammatory, tolerogenic and immunoinhibiting properties o

Details Anti-inflammatory, tolerogenic and immunoinhibiting properties o Anti-inflammatory, tolerogenic and immunoinhibiting properties o

1995-02-17

1998-05-05

Ceperley, Mary E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

514885, 530329, A61K 3910, C07K 706

Patent

active

057470405

ABSTRACT:
The present invention is directed to methods of suppressing inflammatory responses, inducing tolerance to an antigen, and suppressing cell adhesion, e.g., involved in metastasis, by the administration of lectin derived carbohydrate binding peptides or derivatives thereof, in particular, peptides capable of binding terminally linked .alpha.-sialic acid(2.fwdarw.6).beta.Gal- and/or .alpha.-sialic acid(2.fwdarw.3).beta.Gal- groups on structures or molecules comprising such groups. Pharmaceutical compositions containing such lectin derived carbohydrate binding peptides or derivatives thereof are also disclosed.

REFERENCES:
patent: 5079353 (1992-01-01), Ratcliffe et al.
patent: 5081034 (1992-01-01), Bevilacqua et al.
patent: 5154923 (1992-10-01), Van Eden et al.
patent: 5157023 (1992-10-01), Lipton
patent: 5198424 (1993-03-01), McEver
Protein Sequences on STN :Quick Reference Guide published by CAS Apr. 1995 p. 12.
Van't Wout et al, Infect. Immun 60(8):3303-3308, 1992.
Sauter et al, Biochemistry 28: 8388-8396, 1989.
Moore GJ, Trends in Pharmacological Sciences 15:124-129, 1994.
Olson et al, J. Medicinal Chemistry 36(21):3039-3049, 1993.
Albelda, et al., In "Integrins and other cell adhesion molecules" The FASEB Journal. 4:2868-2880 (1990).
Aplin, et al., "Complex Carbohydrates of The Extracellular Matrix Structures, Interactions and Biological Roles" Biochim. Biophys. Acta 694:375-418. (1982).
Armstrong, et al., "Maintenance of Biological Activity of Pertussis toxin Radioiodinated While Bound to Fetuin-Agarose" Infect. Immun., 55:1294-1299 (1987).
Armstrong, et al., "Use of glycosyltransferases to Restore Pertussis Toxin Receptor Activity to Asialoagalactofetuin" J. Biol. Chem., 263:8677-8684 (1988).
Barondes, "Developmentally Regulated Lectins". In Cell Interactions and Development: Molecular Mechanisms (Yamada, D.M., Ed.) pp. 185-202 (1983).
Bevilacqua, et al., "Endothelial-Leukocyte Adhesion Molecule--1 (ELAM-1):A Vascular SELECTIN That Regulates Inflammation." In Cellular and Molecular Mechanisms of Inflammation vol. 2, pp. 1-13 (1991).
Bhavanandan, et al., The Interaction of Wheat Germ Agglutinin with Sialoglycoproteins J. Biol. Chem., 254:4000-4008 (1979).
Brandley, et al., "Cell-Surface Carbohydrates in Cell Recognition and Response" J. Leukocyte Biol., 40:97-111 (1986).
Brennan, et al., "Lectin-like binding of Pertussis Toxin to a 165-Kilodalton Chinese Hamster Ovary Cell Glycoprotein" J. Biol. Chem., 263:4895-4899 (1988).
Chou, et al., "Empirical Predictions of Protein Conformation" Annu. Rev. Biochem., 47:251-276 (1978).
Coutinho, et al., "T Cell-Dependent B Cell Activation" Immunol. Rev., 78:211-224 (1984).
Ekblom, et al., "The Extracellular Matrix and Kidney Differentiation" In Membranes in Growth and Development, Hoffmann et al., Eds., pp. 429-442, (1982).
Frazier, et al., "Surface Components and Cell Recognition" Annu. Rev. Biochem., 48:491-523 (1979).
Furukawa, et al., "Interaction of Sialoglycoproteins with Wheat Germ Agglutinin-Sepharose of Varying Ratio of Lectin to Sepharose" J. Biol. Chem., 261:7755-7761 (1986).
Glaser, "From Cell Adhesion to Growth Control" Mediator of Developmental Processes, (Substency, S. and Wessels, N.K., Eds.), pp. 79-97 (1980).
Hakomori, "Aberrant Glycosylation in Tumors and Tumor-Associated Carbohydrate Antigens" Adv. Cancer Res., 52:257-331 (1989).
Heerze, et al., "Comparison of the Lectin-Like Activity of Pertussis Toxin with Two Plant Lectins That Have Differential Specificities for .alpha.(2-6) And .alpha.(2-3)-Linked Sialic Acid" Biochem and Biophys. Res. Comm., 172:1224-1229 (1990).
Heerze, et al., "Synthesis and Characterization of a Pertussis Toxin-Biotin Conjugate" Biochem and Biophys. Res. Comm., 179:1464-1469 (1991).
Heerze, et al., "Investigation of the Lectin-like Binding Domains in Pertussis Toxin Using Synthetic Peptide Sequences," J. Biol. Chem., 268:1-6 (1993).
Hogg, "Roll, roll, roll your leucocyte gently down the vein . . . ," Immunology Today, 13:113-115 (1992).
Hopp, et al., "Prediction of Protein Antigenic Determinants from Amino Acid Sequences" Proc. Natl. Acad. Sci. U.S.A., 78:3824-3828 (1981).
Jacobson, "Beginnings of the Nervous System" Developmental Neurobiology, New York, Plenum Press pp. 5-25, (1978).
Karlsson, "Animal Glycosphingolipids as Membrane Attachment Sites For Bacteria" Annu. Rev. Biochem., 58:309-350 (1989).
Larsen, et al., "PADGEM-Dependent Adhesion of Platelets to Monocytes and Neutrophils is Mediated by a Lineage-Specific Carbohydrate LNF III (CD15)" Cell, 63:467-474 (1990).
Larsen, et al., "P-selectin and E-selectin" J. Biol. Chem., 267:11104-11110 (1992).
Lowe, et al., "ELAM-1-Dependent Cell Adhesion to Vascular Endothelium Determined by a Transfected Human Fucosyltransferase cDNA" Cell, 63:475-485 (1990).
McEver, "Leukocyte Interactions Mediated by GMP-140" In Cellular and Molecular Mechanisms of Inflammation, vol. 2, pp. 15-29 (1991).
Morgan, et al., "Approaches to the Discovery of Non-Peptide Ligands for Peptide Receptors and Peptidases," In Annual Reports in Medical Chemistry. 24:243-252 (1989).
Munoz, "Action of Pertussigen (Pertussis Toxin) on the Host Immune System." In Pathogenesis and Immunity in Pertussis, pp. 173-192 (1988).
Neuberger A., "What Lectins and Carbohydrates ar Made For?" Biol. Cell, 51 (Special Issue), 113-114, 1984.
Nicolson, et al., "Preferential Organ Attachment and Invasion in vitro by B16 Melanoma Cells Selected for Differing Metastatic Colonization and Invasive Properties" Invas. Metas., 5:144-158 (1985).
Nogimori, et al., "Structure-Function Relationship of Islet-Activating Protein Pertussis Toxin: Biological Activities of Hybrid Toxins Reconstituted from Native and Methylated Subunits" Biochemistry, 25:1355-1363 (1986).
Paulson, "Interactions of Animal Viruses with Cell Surface Receptors" In The Receptors, vol. II (Comm., P.M., Ed.), pp. 131-219 (1985).
Pearce-Pratt, et al., "Simple Calorimetric Cell-13 Cell Adhesion Assay Using Biotinylated Lymphocytes" J. Imm. Methods, 140:159-165 (1991).
Phillips, et al., "ELAM-1 Mediates Cell Adhesion by Recognition of a Carbohydrate Ligand Sialyl-Le.sup.X " Science, vol. 250:1130-1132 (1990).
Reuter et al. Schauer Editor, "Sialic Acids," In Cell Biology Monographs, vol. 10 Schauer, Ed. (1982).
Reuter, et al, "Suggestions on the Nomenclature of Sialic Acids" Glycoconjugates 5:133-135 (1988).
Sato, et al., "Bordetella pertussis Infection in Mice: Correlation of Specific Antibodies Against Two Antigens, Pertussis Toxin, and Filamentous Hemagglutinin with Mouse protectivity in an Intracerebral for Aerosol Channel System" Infect. Immun., 46:415-421 (1986).
Schwartz, et al., "Interaction Between Antigen-Presetting Cells and Primed T Lymphocytes: An Assessment of Ir Gene Expressions in the Antigen-Presenting Cell" Immunol. Rev., 40:153-180 (1978).
Sharon, "Lectin-Like Bacterial Adherance to Animal Cells" In Attachment of Microorganisms to the Gut Mucosa, (Boeheker, E.D., Ed.), pp. 129-147 (1984).
Sleytr, et al., "Structural and Chemical Characterization of S-layers of Selected Strains of Bacillus stearothermophilus and Desulfotomaculum nigrificans" Arch. Microbiol., 146:19-24 (1986).
Smets, et al., "Tumor Cell Surface Carbohydrate," In Membranes in Tumor Growth, Galeotti, et al., Eds., pp. 77-81, (1982).
Smith, et al., "Cyclophosphamide and Dimethyl Dioctadecyl Ammonium Bromide Immunopotentiate the Delayed-Type Hypersensitivity Response to Inactivated Enveloped Viruses" Immunology, 58:245-250 (1986).
Smith, et al., "Induction of Delayed-Type Hypersensitivity to Measles Virus in Mice" Cell. Imm., 89:20-29 (1984).
Springer, et al., "Sticky Sugars for Selectins" Nature, 349:196-197 (1991).
Tamura, et al., "A Role of the B-Oligomer Moiety of Islet-activating Protein, Pertussis Toxin, in Development of Biological Effects on Intact Cells" J. Biol. Chem., 258:6756-6761 (1983).
Trinkaus, "The Molecular Structure of the Cell Surface" Cells into Organs, pp. 44-68, (1984).
Tuomanen, et al., "Preceptor Analogs and Monoclonal Antibodies That Inhibit Adherence of Bordetella pertussis To Human Ciliated Respiratory Epithelial Cells" J. Exp. Med

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