Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-10-29
1988-03-29
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514395, 514397, 514398, 514400, 544318, 548327, 548329, 548336, 548337, H61K 31415, H61K 31505, C07D23384, C07D23938
Patent
active
047344210
ABSTRACT:
Substituted 2-benzyl-mercapto-imidazoles and analogs were prepared from the nucleophlic substitution of an appropriately substituted benzoxyacetate with a 2-imidazole mercapto anion or an analog thereof. These compounds were found to be anti-inflammatory agents.
REFERENCES:
March et al., Textbook "Adv. Org. Chem", 2nd Ed., McGraw-Hill, N.Y., N.Y., 1977, pp. 374, 375 and 596-598.
Shen et al., "The Development of Anti Asthmatic Drugs", Part III, Butterworth Publishers, 1983, Kent, England, 315-317 and 331-335.
Hammond Milton L.
Zambias Robert A.
Cheng Theresa Y.
Jiles Henry R.
Merck & Co. , Inc.
Mullins J. G.
Sudol Michael C.
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