Anti-inflammatory substituted 2-benzyl-mercapto-imidazole and py

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514395, 514397, 514398, 514400, 544318, 548327, 548329, 548336, 548337, H61K 31415, H61K 31505, C07D23384, C07D23938

Patent

active

047344210

ABSTRACT:
Substituted 2-benzyl-mercapto-imidazoles and analogs were prepared from the nucleophlic substitution of an appropriately substituted benzoxyacetate with a 2-imidazole mercapto anion or an analog thereof. These compounds were found to be anti-inflammatory agents.

REFERENCES:
March et al., Textbook "Adv. Org. Chem", 2nd Ed., McGraw-Hill, N.Y., N.Y., 1977, pp. 374, 375 and 596-598.
Shen et al., "The Development of Anti Asthmatic Drugs", Part III, Butterworth Publishers, 1983, Kent, England, 315-317 and 331-335.

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