Anti-inflammatory products derived from methylene-diphosphonic a

Details Anti-inflammatory products derived from methylene-diphosphonic a Anti-inflammatory products derived from methylene-diphosphonic a

1986-04-24

1988-05-24

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

26050121, 514824, 514877, 558155, A61K 3166, C07F 938

Patent

active

047466545

ABSTRACT:
The present invention relates to products of the formula ##STR1## where R.sub.1 is H or alkyl, n is an integer from 0 to 10, and R.sub.2 is chosen from amongst H, unsubstituted or substituted alkyl radicals, a ##STR2## a substituted or unsubstituted phenyl radical, a ##STR3## where X is oxygen or sulfur, or a heterocyclic radical with 5 or 6 members, which may or may not be fused to a benzene ring and R.sub.3 is H or OH.
The present invention also relates to a process for the preparation of the products of the formula (I), and to the drugs, having in particular an anti-inflammatory effect, containing a product of the formula (I).

REFERENCES:
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patent: 3683080 (1972-08-01), Francis
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patent: 3957858 (1976-05-01), Kerst
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patent: 4264582 (1981-04-01), Flora et al.
Chemical Abstracts, vol. 93, No. 25, 22 Dec. 1980, p. 877, 239648z (Columbus, Ohio, US) & JP-A-80 98 193 (Nissan Chemical Industries Ltd.), 25 Jul. 1980.
Synthesis, No. 2, Feb. 1980, Georg Thieme Verlag, Stuttgart, N.Y., M. Mikolajczyk et al, "Sulphenylation of Phosphonates. A Facile Synthesis of Alpha-Phosphoryl Sulphides and S,S-Acetals of Oxomethanephosphonates", pp. 127-129.

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