Anti-inflammatory polypeptide antagonists of human I1-8

Details Anti-inflammatory polypeptide antagonists of human I1-8 Anti-inflammatory polypeptide antagonists of human I1-8

1996-06-28

1999-06-15

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 14, 514 15, 514825, 514886, 530324, 530325, 530326, 530327, 530328, A61K 3800

Patent

active

059122323

ABSTRACT:
Polypeptides derived from human interleukin-8 (IL-8) or other alpha chemokines which act as anti-inflammatory agents for the therapy of autoimmune disease, inflammatory conditions, and various chronic inflammatory diseases such as rheumatoid arthritis and psoriasis.

REFERENCES:
patent: 5079228 (1992-01-01), Cohen et al.
Clark-Lewis, Ian, et al., Structure-Activity Relationships of Interleukin-8 Determined Using Chemically Synthesized Analogs, J of Bio Chem, vol. 266, No. 34, Dec. 5, 1991.
Moser, Bernhard, et al., Interleukin-8 Antagonists Generated by N-terminal Modification, J of Bio Chem, vol. 268, No. 10, Apr. 5, 1993.
Baldwin, Eric T., et al., Crystal structure of interleukin 8: Symbiosis of NMR and crystallography, Proc. Natl. Acad. Sci. USA, vol. 88, Jan. 1991.
Clark-Lewis, Ian, et al., Platelet factor 4 binds to interleukin 8 receptors and activates neutrophils when its N terminus is modified with Glu-Leu-Arg, Proc. Natl. Acad. Sci. USA vol. 90, Apr. 1993.
Clark-Lewis, Ian, et al., Structural Requirements for Interleukin-8 Function Identified by Design of Analogs and CXC Chemokine Hybrids, J. of Bio Chem, vol. 269, No. 23, Jun. 10, 1994.
Clore, G. Marius, et al., Determination of the Secondary Structure of Interleukin-8 by Nuclear Magnetic Resonance Spectroscopy, J. of Bio Chem, vol. 264, No. 32, Nov. 15, 1989.

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